BNP及CRP在急性冠状动脉综合征患者外周血中的表达及其与病变严重程度的相关性  

Expression of BNP and CRP in peripheral blood of ACS patients and their relationships with disease severity degree

作　　者：王静[1] 廖荣宏[1] 

机构地区：[1]重庆医科大学附属永川医院心内科,重庆402160

出　　处：《实用临床医药杂志》2015年第9期18-20,31,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨脑利尿钠肽(BNP)及C反应蛋白(CRP)在急性冠状动脉综合征(ACS)患者外周血中的表达及其与病变严重程度的相关性。方法选取98例ACS患者设为ACS组,根据Genisis积分进一步分为轻度组35例、中度组33例、重度组30例。另选取同期稳定性心绞痛(SA)患者30例设为SA组,同期冠状动脉造影正常者32例设为对照组。检测各组血清CRP及BNP水平,并分析其与病情严重程度的相关性。结果 ACS组血清CRP及BNP均高于SA组和对照组(P<0.01),SA组和对照组之间无统计学差异(P>0.05);STEMI、NSTEMI和UA患者CRP和BNP水平,与重、中、轻度组的CRP和BNP水平均呈逐渐下降趋势,两两比较差异有统计学意义(P<0.05或P<0.01)。相关性分析表明,血清CRP和BNP水平均与Genisis积分呈正相关(r=0.479,0.702,P<0.01)。结论 ACS患者外周血中CRP和BNP表达水平高于SA患者及健康人群,且与病情严重程度密切相关,检测相关指标可作为临床诊治及预后评估的参考指标。Objective To explore the expression of brain natriuretic peptide（BNP） and Creactive protein（CRP） in the peripheral blood of patients with acute coronary syndrome（ACS） and their relationships with the disease severity degree. Methods A total of 98 ACS patients served as ACS group and were further divided into mild group（n = 35）,moderate group（n = 33） and severe group（n = 30） according to Genisis score. Another 30 patients diagnosed as stable angina（SA） and32 normal people undergoing coronary angiography（CAG） in corresponding period were selected as SA group and control group,respectively. Serum CRP and BNP levels of both groups were detected to analyze their relationships with disease severity degree. Results Serum CRP and BNP levels were evidently higher in ACS group than in SA group（P〈 0. 01）,but there was no significant difference between SA group and control group（P〉0. 05）. CRP and BNP levels showeda decreasing trend in patients with ST-elevated myocardial infarction（STEMI）,non-STEMI（NSTEMI） and unstable angina（UA） as well as in mild,moderate and severe groups,and there were significant differences among groups（P〈 0. 05 or P〈 0. 01）. Relevance analysis indicated that serum CRP and BNP levels were in positive association with Genisis score（r = 0. 479,0. 702,P〈 0. 01）. Conclusion Peripheral blood CRP and BNP levels are higher in ACS patients than in SA patients and healthy populations,and are in close connection with the disease severity degree,so their detections can be used as reference indexes for the clinical diagnosis and treatment as well as prognostic evaluation of ACS patients.

关 键 词：脑利尿钠肽 C反应蛋白 急性冠状动脉综合征 急性ST段抬高型心肌梗死 急性非ST段抬高型心肌梗死 不稳定性心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]