致病性曲霉的耐药性研究进展  

The progress in antifungal resistance of pathogenic Aspergillus spp.

作　　者：王千[1,2] 李若瑜[1,2] 刘伟[1,2] 

机构地区：[1]北京大学第一医院皮肤性病科 [2]北京大学真菌与真菌病研究中心皮肤病分子诊断北京市重点实验室,北京100034

出　　处：《微生物与感染》2015年第2期116-121,共6页Journal of Microbes and Infections

基　　金：国家自然科学基金(81471925);教育部"新世纪人才支持计划"(NCET-10-0198)

摘　　要：随着抗真菌药物在临床上的广泛使用,致病性真菌的耐药率越来越高,耐药曲霉对侵袭性曲霉病的诊治产生了重要影响。目前,致病性曲霉耐药性的确定主要依靠抗真菌药敏试验和分子诊断。在有关曲霉耐药机制的研究中,报道最多的是曲霉对唑类药物的耐药,其机制主要包括外排泵表达增加、靶酶Cyp51突变和表达水平增高、形成生物膜,以及热休克蛋白90(Hsp90)介导的信号通路参与而导致的耐药。本文就上述领域近年来的主要进展进行综述。With the wide use of antifungals in the clinic ,there have been increasing reports of resistant strains of Aspergillus spp .to antifungals .The resistance of Aspergillus spp .has important impact on the diagnosis and treatment of invasive aspergillosis .Currently ,the determination of antifungal resistance of pathogenic Aspergillus spp .relies on antifungal susceptibility testing and molecular detection .Recently ,the resistance of Aspergillus spp .to antifungals is mainly focused on azole antifungals .The research progress on antifungal resistance of pathogenic Aspergillus spp ., including the diagnosis for resistance and the molecular mechanisms ,such as over‐expression of efflux pumps ,mutations in the target enzyme （Cyp51） ,formation of biofilm and heat shock protein 90 （Hsp90）‐mediated signaling pathways are reviewed .

关 键 词：曲霉 耐药 唑类抗真菌药物 

分 类 号：R379[医药卫生—病原生物学]