纳米镍修饰的氧化铜掺杂的异戊巴比妥电化学传感器制备与应用  

Preparation and application of a novel amobarbital electrochemical sensor based on Ni nanoparticles modified glassy carbon and CuO nanoparticles doping

作　　者：黄学艺[1] 余会成[1] 韦贻春[1] 李浩[1] 雷福厚 谭学才[1] 米丹丹[1] 吴海鹰[2] 

机构地区：[1]广西民族大学化学化工学院广西林产化学与工程重点实验室广西高校食品安全与药物分析化学重点实验室,南宁530006 [2]广州有色金属研究院,广州510651

出　　处：《分析试验室》2015年第5期510-514,共5页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金(21365004);广西自然科学重点基金(2013GXNSFDA019006);广西高等学校高水平创新团队及卓越学者资助计划(桂教人[2014]7号);广西研究生教育创新计划资助项目(YCSZ2014120)资助

摘　　要：先将合成的纳米镍修饰裸玻碳电极,再在修饰电极表面热聚合一种以甲基丙烯酸为功能单体、马来松香丙烯酸乙二醇酯为交联剂、纳米氧化铜掺杂的异戊巴比妥分子印迹敏感膜。研究了印迹电极的最佳成膜条件及其最佳实验条件。采用循环伏安法（CV）和电化学交流阻抗法（EIS）对印迹传感器的电化学性能进行表征。使用红外光谱和扫描电镜分别探究此印迹敏感膜的结构及表面形貌。在最佳实验条件下,以K3Fe（CN）6为分子探针的差分脉冲伏安法（DPV）峰电流响应值与异戊巴比妥的浓度在6.5×10-8~1.8×10-4mol/L范围内呈现良好的线性关系（线性相关系数R=0.9986）;检出限为1.1×10-9mol/L（S/N=3）。传感器能用于猪肉中残留异戊巴比妥的检测,加标回收率在96.5%~103.2%之间。Uniform nickel nanoparticles were synthesized and modified on the surface of glassy carbon electrode. The molecularly imprinted polymer （MIP） films doped with CuO nanoparticle for the determination of amobarbitalwere prepared by thermal polymerization method with methacrylic acid as functional monomers, and ethylene glycol maleic rosinate acrylate as a cross linking agent. The optimum experimental conditions were explored. The electrochemical properties of the nano - doped sensor were investigated using cyclic vohammetry （CV） and electrochemical impedance spectroscopy （EIS）. The structure and morphologies of the imprinted films were characterized using infrared （IR） spectroscopy and scanning electron microscopy （SEM）. Under the optimal conditions, the relative redox peak currents of hexacyanoferrate showed a linear dependence on the amobarbital concentration in the range from 6. 5 × 10 -5 to 1.8 × 10 -4 mol/L （ linear regression coefficient R = 0.9986） with a detection limit of 1.1 × 10-9 mol/L （S/N = 3）. The prepared sensor was successfully applied for the determination of amobarbital in pork samples and the recovery ranged from 96.5% to 103.2%.

关 键 词：异戊巴比妥 马来松香丙烯酸乙二醇酯 纳米氧化铜 纳米镍 电化学传感器 

分 类 号：O657.1[理学—分析化学]