内蒙古汉族人群维生素D受体FokI基因多态性与斑秃的关系  

Relationship between vitamin D receptor gene FokI polymorphism and alopecia areata in Inner Mongolian Han population

作　　者：卓纳[1] 张满[1] 辛燕[2] 

机构地区：[1]内蒙古医科大学附属医院皮肤科,内蒙古呼和浩特010050 [2]内蒙古医科大学第三附属医院皮肤科,内蒙古包头014010

出　　处：《中国麻风皮肤病杂志》2015年第4期198-200,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:明确维生素D受体FokI基因多态性与内蒙古汉族人群斑秃的相关性。方法:运用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)技术,检测105例斑秃患者与145名健康对照的维生素D受体基因FokI酶切位点的多态性。结果:病例组维生素D受体FokI的3种基因型FF、Ff、ff频率分别为0.324、0.524、0.152,对照组分别为0.297、0.531、0.172,两组间比较无显著性差异(P>0.05)。结论:维生素D受体FokI基因多态性可能与内蒙古汉族人群斑秃的发病无关。Objective：To determine the relationship between the polymorphism of vitamin D receptor gene FokI and alopecia areata in Inner Mongolia Han population. Methods：The polymorphism of vitamin D recep-tor Gene FokI sites in patients with alopecia areata （105 patients） and healthy controls （145 patients） were detected by PCR-RELP. Results：The genotype frequencies of FF, Ff and ff in patients were 0.324, 0.524, 0.152 and those in healthy controls were 0.297, 0.531, 0.172. There were no significant difference between the patients and the controls （P〉0.05）. Conclusion： There is no relationship between the polymorphism of vitamin D receptor FokI and alopecia areata in Inner Mongolia Han population.

关 键 词：斑秃 维生素D受体 FokI基因多态性 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]