水通道蛋白的表达与关节炎关系的研究进展  

Research progress on the relationship between expressions of aquaporins and arthritis

作　　者：冯芳芳[1] 于超[1] 谭春江 陈文列 陈赛楠[1] 

机构地区：[1]福建中医药大学,福州350122 [2]福建中西医结合研究院 [3]福建省中西医结合老年性疾病重点实验室 [4]国家中医药三级科研实验室-中药药理 ( 细胞结构与功能 ) 实验室

出　　处：《中国骨与关节杂志》2015年第4期323-327,共5页Chinese Journal of Bone and Joint

基　　金：福建省自然科学基金(2014J01356);福建省科技重大项目(2012Y4006);国家自然科学基金项目(81202836)

摘　　要：关节炎泛指在人体关节及其周围组织中一类非特异炎性疾病，种类较多，病因复杂，目前认为该类疾病与各种炎症促发因子、自身免疫反应、病原微生物感染、代谢紊乱、创伤、退行性病变等多种因素有关。近年来研究多围绕软骨退变、滑膜病变等引起的炎症展开，取得了突破性成果。Aquaporins （ AQPs ） act as an important channel for body water crossing the cell membrane, and are closely related to the balance of water metabolism and water reserves. Recent studies have found that there are signiifcant differences in the expressions of AQPs in arthritis joints and normal joints. The expressions of AQP1, AQP3 and AQP9 in the patients with rheumatoid arthritis and osteoarthritis are all signiifcantly increased, which are enhanced with the occurrence of lesions. The expressions of AQP4 are higher in the patients with gouty arthritis and osteoarthritis than in the patients with normal joints, which can reflect the severity of articular diseases. After medication, the expressions of AQPs are remarkably reduced, and the arthritis symptoms are improved. It points out that a special intimate relationship exists between the upregulation of the expressions of AQPs in arthritis joints and the occurrence and development of pathological changes. With AQPs as therapeutic targets, the cell membrane permeability to water can be reduced through regulation, so as to improve inlfammation. It offers a new research idea for the prevention and control of arthritis. In this paper, the studies on the relationship between AQPs and arthritis in recent years are reviewed.

关 键 词：水通道蛋白质1 水通道蛋白质3 水通道蛋白质4 水通道蛋白质9 骨关节炎 关节 炎 类风湿性 

分 类 号：R684.3[医药卫生—骨科学]