子痫前期的遗传学及分子生物学研究进展  

Advances in Genetics and Molecular Biology of Preeclampsia

作　　者：胡志英[1] 童晓文[1] 

机构地区：[1]同济大学附属第十人民医院妇产科,上海200072

出　　处：《医学综述》2015年第8期1377-1379,共3页Medical Recapitulate

摘　　要：子痫前期以新发的高血压和蛋白尿为特征,是一种严重的妊娠合并症。其发病机制涉及氧化应激、内皮功能失调、血管收缩、代谢改变、血栓性疾病及免疫反应等。目前的主流观点认为,子痫前期是与遗传和环境因素相关的多基因疾病,并且越来越多的研究发现,母体和胎儿的遗传基因改变是子痫前期发病的重要因素。Preeclampsia is characterized by newly onset hypertension and proteinuria and is a major pregnancy complication.The pathogenesis involves oxidative stress,endothelial dysfunction,vasoconstriction, metabolic changes, thrombotic disease and immune response,etc.At present the mainstream view is that pre-eclampsia is a polygenic disease associated with genetic and environmental factors ,and a growing number of studies have found that maternal and fetal genetic change is an important factor in the pathogenesis of pre-eclampsia.

关 键 词：子痫前期 基因 妊娠 

分 类 号：R34[医药卫生—基础医学]