红细胞分布宽度与原发性高血压患者动脉僵硬度的关系  

Study on the Ralationship between Red Blood Cell Distribution Width and Arteriosclerosis in Patients with Essential Hypertension

作　　者：张艳霞[1] 杨登云[1] 李海芹[1] 崔勇波 陈桂玲[1] 

机构地区：[1]安阳市第三人民医院心内科,河南安阳455000

出　　处：《医学综述》2015年第8期1483-1485,共3页Medical Recapitulate

摘　　要：目的探讨红细胞分布宽度(RDW)与原发性高血压患者动脉僵硬度的相关性。方法选择2011年9月至2012年9月在安阳市第三人民医院确诊的原发性高血压患者327例,根据RDW数值(CV%)分为A1组(103例):10.0%<RDW≤12.0%、A2组(91例):12.0%<RDW≤14.0%、A3组(80例):14.0%<RDW≤16.0%、A4组(53例):RDW>16.0%,采集受试者清晨空腹静脉血,测定红细胞数、血红蛋白、RDW,所有患者行颈动脉超声测定颈动脉内膜-中层厚度(IMT),并行踝臂指数、踝臂脉搏波传导速度(ba PWV)测定,比较各组患者动脉硬化指标的差异。结果随着RDW的逐级增高,ba PWV、颈动脉IMT也逐级增高,踝臂指数逐级降低,颈动脉斑块检出率有升高趋势。各组患者颈动脉IMT、ba PWV、踝臂指数、颈动脉斑块检出率分别为A1组:(0.7±0.2)mm、(1303±50)cm/s、1.24±0.42、25.2%;A2组:(0.9±0.3)mm、(1486±65)cm/s、1.15±0.40、33.0%;A3组:(1.2±0.1)mm、(1664±61)cm/s、1.02±0.31、40.0%;A4组:(1.4±0.3)mm、(1864±51)cm/s、0.91±0.23、60.4%。各组间比较,差异有统计学意义(P<0.05)。相关性分析显示,RDW与颈动脉IMT、ba PWV呈正相关(r=0.297,P=0.043;r=0.362,P=0.003),与踝臂指数呈负相关(r=-0.283,P=0.037),与斑块检出率呈正相关(rs=0.351,P=0.017)。结论 RDW与原发性高血压患者动脉僵硬度密切相关,可能成为高血压患者动脉僵硬度的独立预测因子。Objective To explore the relevance between rod blood cell distribution width （RDW） and arteriosclerosis in patients with essential hypertension. Methods A total of 327 patients with essential hypertension diagnosed in Anyang Third People＇ s Hospital from Sep. 2011 to Sep. 2012 were selected. According to the RDW levels,the research objects were divided into A1 group（ 103 cases） （RDW 10.0%- 12. 0% ） ,A2 group（91 cases） （RDW 12.0%-14. 0% ） ,A3 group（80 cases） （ RDW 14.0%-16. 0% ） ,A4 group（53 cases） （ RDW 〉 16. 0% ）. The levels of RDW, ankle brachial index, ankle-brachial pulse wave velocity （baPWV）, carotid intima-media thickness （CA- IMT） of the four groups were measured and com- pared. Results As RDW increased step by step, levels of CA-IMT, baPWV, detection rate of carotid artery plaque increasd step by step, while ankle brachial index dropped. Levels of CA-IMT, baPWV, ankle brachial index and detection rates of carotid artery plaque of the four groups respectively were ： AI group （ 0. 7 ± 0.2） mm, （1304±50） cm/s,1.24±0.42,25.2%;A2 group （0.9±0.3） mm,（1486±65） cm/s,1. 15± 0.40,33.0%;A3 group （1.2 ±0.1） mm,（1664 ±61） cm/s,1.02 ±0.31,40.0%;A4 group （1.4±0. 3 ） mm, （ 1864 ± 51 ） cm/s ,0. 91 ± 0.23,60. 4%. There were statistically significant differences among the groups（ P 〈 0. 05 ）. Moreover, correlation analysis showed that levels of CA-IMT, baPWV and detection rate of carotid artery plaque were positively correlated with RDW （ r = 0. 297, P = 0. 043 ; r = 0. 362, P = 0. 003 ;L = 0. 351, P = 0. 017 ）. A negative correlation was observed between RDW and ankle braehial index （ r = - 0. 283, P = 0. 037 ）. Condusion RDW can be a independent predictor of arterial stiffness of hyper- tension oatients due to its close correlation with arteriosclerosis in patients with essential hypertension.

关 键 词：原发性高血压 红细胞分布宽度 踝臂指数 踝臂脉搏波传导速度 颈动脉内膜-中层厚度 

分 类 号：R544.1[医药卫生—心血管疾病] R446.111[医药卫生—内科学]