铜绿假单胞菌耐药性与致病性共选择机制研究进展  

Progress on co-selection mechanism of antibiotics resistance and virulence in Pseudomonas aeruginosa

作　　者：宁唤唤 李晶[1] 王严[1] 李博[1] 王波波[1] 张悦[1] 陈林[1] 沈立新[1] 

机构地区：[1]西北大学生命科学学院西部资源与现代生物技术省部共建教育部重点实验室,西安710069

出　　处：《中国抗生素杂志》2015年第5期382-388,400,共8页Chinese Journal of Antibiotics

基　　金：国家自然科学基金NSFC(No.81171620;No.1210063);西北大学省级大学生创新训练计划项目(No.0795)

摘　　要：世界范围内细菌耐药性问题日益严重状况下,包括铜绿假单胞菌(Pseudomonas aeruginosa,PA)在内的病原微生物的致病性与耐药性的共选择、共进化现象引起了人们越来越多的关注和不断深入的研究,这将有助于优化临床治疗方案,为药物治疗和筛选提供新靶点。本文综述了PA致病性与耐药性共选择机制的遗传物质基础,并简单讨论二者变化关系及相关应用。Antibiotics resistance of bacteria has accelerated around the world nowadays. More and more multidrug-resistant pathogens with increased pathogenicity emerged in clinic and caused much more problems in human health all over the world. Co-selection is one of the most important mechanisms that favor the persistence of the resistant pathogens and the selection of the most virulent and most resistant pathogens. Pseudomonas aeruginosa is an important pathogen, capable of causing serious and often life-threatening infection in humans because of its resistance to many kinds of antibiotics as well as the large arsenal of virulence factors. P aeruginosa has joined the ranks of these most virulent and most resistant ＂superbug＂. The progress on the co-selection of resistance and virulence in P. aeruginosa and the sequent aoolication in clinic have been reviewed in this oaoer.

关 键 词：铜绿假单胞菌 耐药性 致病性 共选择 共进化 

分 类 号：R378[医药卫生—病原生物学]