万古霉素不同给药方式对血清蛋白代谢的影响  

The Influnce of Vancomycin on Serum Proteins by Two Different Administration

作　　者：杨逢永[1] 吴玉成[1] 郭立峰[1] 陈晨[1] 段崇浩[1] 李学军[1] 

机构地区：[1]泰山医学院附属莱芜市人民医院ICU,山东省莱芜市271199

出　　处：《医学理论与实践》2015年第7期844-845,共2页The Journal of Medical Theory and Practice

基　　金：莱芜市科技局专项科研立项项目(20120318)

摘　　要：目的:探讨万古霉素不同给药方式对血清蛋白代谢的影响。方法:回顾性分析ICU既往收治MRSA感染患者96例,在我科开展PK/PD模型引导抗生素治疗方案之前按照常规给予万古霉素治疗52例及按照PK/PD模型引导给药44例,比较两组治疗后尿微量蛋白阳性率差异。结果:PK/PD治疗组患者尿微量蛋白阳性率明显低于常规给药组。结论:PK/PD模型引导万古霉素治疗优化方案可以明显减轻患者肾损害,维持血清蛋白代谢的稳定。Objective ：To discuss the influence of Vancomycin on serum proteins by two different administration .Meth‐ods：A total of 96 patients infected with MRSA administrated Vancomycin by two different ways ,the conventional way and the PK/PD modeling guiding way .Then compare positive rate of urinary microproteins of two groups .Results：The positive rate of urinary microproteins of group conventional way was significantly higher than that of group PK /PD Modeling Guiding way .Conclusion：Application of Vancomycin by PK/PD Modeling Guidingway can significantly re‐duce renal damage and Maintain concentration of serum proteins stable .

关 键 词：万古霉素 血清蛋白 尿微量蛋白 PK/PD模型引导 

分 类 号：R978[医药卫生—药品]