骨形态发生蛋白7在慢性肾脏疾病纤维化中作用研究进展  

Research Advances in the Role of Bone Morphogenetic Protein-7 in Fibrosis of Chronic Kidney Disease

作　　者：刘道勤[1] 张道友[1] 

机构地区：[1]皖南医学院第一附属医院肾脏内科,安徽芜湖241001

出　　处：《医学综述》2015年第9期1579-1581,共3页Medical Recapitulate

摘　　要：骨形态发生蛋白7(BMP-7)是一个对肾脏有保护作用的细胞因子,具有维持肾脏组织结构和功能的重要作用。作为转化生长因子β1的拮抗剂,BMP-7是体内一种强有力的抗纤维化因子,能抑制或逆转肾纤维化,改善肾功能。该文就近年BMP-7在慢性肾脏病纤维化中的作用及机制进行综述,期待BMP-7今后在治疗慢性肾脏病纤维化中开辟新的途径。In recent years, bone morphogenetic protein-7 （BMP-7） has been found as a protective cyto- kine on the kidneys. BMP-7 plays an important role in maintaining the structure and function of the kidneys. As the antagonist of transforming growth factor-131 ,BMP-7 is a potent in vivo anti-flbrotic factor to inhibit or reverse renal fibrosis and improve kidney function. Here is to make a review of the roles and mechanisms of BMP-7 in the fibrosis of chronic kidney disease, aiming at exploring new pathway in the treatment for fibrosis of chronic kidney disease.

关 键 词：骨形成蛋白7 慢性肾脏疾病 肾纤维化 

分 类 号：R692[医药卫生—泌尿科学]