细菌性肺炎患者血清降钙素原和超敏C反应蛋白水平分析  

Detection of Serum Levels of Procalcitonin,High-sensitivity C-reactive Protein in Bacterial Pneumonia Patients

作　　者：马清峰[1] 熊亮[1] 

机构地区：[1]华中科技大学同济医学院附属梨园医院检验科,武汉430076

出　　处：《微循环学杂志》2015年第2期41-43,共3页Chinese Journal of Microcirculation

摘　　要：目的:分析血清降钙素原(PCT)和超敏C反应蛋白(hs-CRP)水平与细菌性肺炎的关系。方法:按严重程度综合评分将127例下呼吸道细菌性肺炎患者(细菌性肺炎组)分为Ⅰ级40例,Ⅱ-Ⅲ级49例,Ⅳ-Ⅴ级38例;采用荧光免疫分析技术测定血清PCT水平,采用全自动免疫比浊法测定血清hs-CRP浓度,统计学分析其与35例下呼吸道非细菌性肺炎患者(非细菌性肺炎组)及20例健康体检者(对照组)的差异及细菌性肺炎严重程度与PCT和hs-CRP的相关性。结果:与对照组和非细菌性肺炎组相比,细菌性肺炎组血清PCT、hs-CRP水平均显著增高(P<0.01);且细菌性肺炎严重程度与患者血清PCT、hs-CRP水平呈显著正相关(r分别为0.993、0.976,P均<0.05)。结论:血清PCT和hs-CRP水平升高有助于鉴别下呼吸道细菌性和非细菌性感染,还能反映细菌性肺炎的严重程度。Objective：To investigate the relationship between the serum levels of procalcitonin（PCT）,high-sensitivity C-reactive protein（hs-CRP）and bacterial pneumonia.Method：According to the pneumonia severity in-dex,127 patients with bacterial pneumonia were divided into level I （40 cases）,II-III level（49 cases）and IV-V level （38 cases）;PCT levels were detected by the fluorescence immunoassay technology,hs-CRP levels were detec-ted by the full automatic immune turbidimetry,the differences were analyzed by the statistical analysis among bacte-rial pneumonia,35 cases of non-bacterial pneumonia and 20 cases of healthy check-up （control group）,the correla-tion of severity of bacterial pneumonia and the levels of PCT,hs-CRP were analyzed.Results：The serum levels of PCT and hs-CRP in patients with the bacterial pneumonia were significantly higher than the control group and the non-bacterial pneumonia group（P〈0.01）,serum PCT and hs-CRP levels were positive correlated with the increas-ing degree of pneumonia（r was 0.993,0.976 respectively,P〈0.05）.Conclusion：High serum levels of PCT and hs-CRP contributed to the difference between the lower respiratory tract bacterial and non-bacterial infection,also could reflect the severity of bacterial pneumonia.

关 键 词：细菌性肺炎 降钙素原 超敏C反应蛋白 

分 类 号：R446.11[医药卫生—诊断学]