左西替利嗪联合地氯雷他定治疗儿童慢性荨麻疹多中心临床观察  

The Multicenter Study of Sesloratadine Combined Levocetirizine Therapy on Chronic Urticaria in Children

作　　者：胡伟 马慧群[2] 闫小宁 牟宽厚[4] 曹伟[5] 牛新武[2] 

机构地区：[1]武警陕西省总队医院儿科,陕西西安710054 [2]西安交通大学医学院第二附属医院皮肤科,陕西西安710004 [3]陕西省中医医院皮肤科,陕西西安710004 [4]西安交通大学医学院第一附属医院皮肤科,陕西西安710006 [5]宝鸡市中心医院皮肤科,陕西宝鸡721008

出　　处：《中国皮肤性病学杂志》2015年第5期481-483,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的观察左西替利嗪联合地氯雷他定治疗儿童慢性荨麻疹的临床疗效及安全性,探讨其可能的作用机制。方法将多中心符合入选标准的354例儿童慢性荨麻疹患者,随机分为3组,对照1组给予地氯雷他定2.5mg(2~6岁)或5mg(7~12岁)口服,每晚1次,连用6周;对照2组给予左西替利嗪2.5mg(2~6岁)或5mg(7~12岁)晨服,1次/d,连用6周;治疗组每日晨服左西替利嗪,连用3周,同时每晚口服地氯雷他定,连用6周,剂量同前。疗程结束时观察临床疗效,同时比较该3组患者治疗前、后血清Ig E水平变化情况。结果治疗组患者起效速度均明显高于其他两组患者,而且其疗效随着治疗时间的延长均上升显著。治疗结束时,治疗组有效率为93.22%,对照1组有效率为81.20%,对照2组为78.95%,治疗组有效率优于对照组(P均<0.01)。3组血清Ig E水平在治疗6周后均显著下降(P<0.01),同时治疗组Ig E水平下降幅度高于对照组(P<0.01)。结论左西替利嗪联合地氯雷他定治疗儿童慢性荨麻疹起效快、临床疗效好。Objective To evaluate the efficacy and safety of desloratadine combined levocetirizine therapy on chronic urticaria in children. Methods In this multicenter study,354 patients with chronic urticaria form 5 hospitals in Shaanxi Province were randomly divided into three groups. Consider their ages and weight the patients in control group 1 were given 2.5mg or 5mg desloratadine orally every night for 6 weeks, while those in control group 2 were given 2.5mg or 5mg levocetirizine every morning, the children in observing group were given both levocetirizine every morning for 3 weeks, and desloratadine every night for 6 weeks. The serum IgE was detected in 3 groups. Results There was no lost case in observation group but 1 and 4 cases in control group 1 and control group 2 respectively. The results showed that the therapeutic effect in observation group was better than that in control groups. After 6 weeks of treatment, the efficiency in observation group （93.22%） were significantly higher than that in group 1 （ 81.20% ） and control group 2 （78.95 % ） （ P 〈 0.01 ）. The se- rum IgE levels in three groups were decreased significantly than that before treatment, and that in observation group was significantly lower than in the control groups after the treatment for 6 weeks （ P 〈 0.05 ）. Conclu- sion The desloratadine combined levocetirizine therapy, which has the advantage of operating quickly, is a effective method on chronic urticaria in children.

关 键 词：多中心随机对照 儿童 慢性荨麻疹 地氯雷他定 左西替利嗪 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]