以特殊皮损为首发临床表现的抗磷脂抗体综合征2例  

Two Cases of Antiphospholipid Syndrome( APS) Presenting with Special Skin Manifestation

作　　者：李子海[1] 侯麦花[2] 鲁严[2] 龚晴丽 王飞[2] 夏济平[2] 张美华[2] 

机构地区：[1]南京市第二医院皮肤科,江苏南京210003 [2]南京医科大学第一附属医院皮肤科,江苏南京210029

出　　处：《中国皮肤性病学杂志》2015年第5期509-510,514,共3页The Chinese Journal of Dermatovenereology

基　　金：江苏省六大人才高峰资助项目(2013-wan031);江苏省教育科学"十二五"规划课题(批准号D/2013/01/015);南京医科大学"十二五"第二期教育研究课题资助

摘　　要：报告2例以不规则多发性皮肤瘀斑和坏死为首发表现的抗磷脂抗体综合征。例1女,42岁。臀部及下肢大片瘀斑、坏死,血小板减少,抗核抗体、抗心磷脂抗体异常升高,补体降低,皮损组织病理示真皮血管有血栓存在。给予抗凝、血管扩张剂、糖皮质激素、免疫抑制剂和静脉注射用人免疫球蛋白等控制病情的同时,外科手术修复大片坏死皮肤。例2女,47岁。腹部、四肢大片瘀斑、水疱,抗心磷脂抗体异常升高,皮损组织病理示真皮浅层小血管血栓形成。给予糖皮质激素治疗及红光照射,皮损恢复较好。We reported two cases of antiphospholipid syndrome （APS） presenting with special skin manifestation. Case one：A 42-year-old female suffered from skin ecchymosis and necrosis on buttocks and legs with thrombocyto- penia,hypocomplementemia, and abnormal elevation of ANA and antiphospholipid antibodies （APL）. Histo- pathology revealed thrombosis in dermis and subcutis. With the treatment of anticoagulation,vasodilation,im- munosuppressant, glucocorticoids intravenous immunoglobulin, the diease is in remission. And then the surgi- cal treatment to restored the large area of the necrotic skin was done. Case two ： A 47-year-old female suffered from skin ecchymosis and blister on limbs and abdomen, with abnormal elevation of antiphospholipid antibod- ies. Histopathology revealed thrombosis in superficial dermis. After treatment with glucocorticoids and red light irradiation, the lesion rehabilitation well.

关 键 词：抗磷脂抗体综合征 特殊皮损 

分 类 号：R593.2[医药卫生—内科学]