国产醋酸钠林格液与8种抗菌药物的配伍稳定性研究  

Study on the compatible stability of antibacterial drugs made with 8 Bell Ringer's acetate

作　　者：李宏岩[1] 邢媛媛[2] 杨伍 霍威[1] 韩宇平[1] 晋学飞[1] 

机构地区：[1]吉林大学中日联谊医院泌尿外科,吉林长春130033 [2]吉林大学中日联谊医院肾病内科,吉林长春130033 [3]湖北博瑞佳医药有限公司,湖北武汉430000

出　　处：《临床医药文献电子杂志》2015年第12期2240-2241,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的观察国产醋酸钠林格液与8种常用抗菌药物配伍后的稳定性。方法观察配伍溶液的外观并测定其p H值、微粒数以及细菌内毒素。结果国产醋酸钠林格液与8种抗菌药物配伍后,样品液均无气体或沉淀产生;p H值、微粒数、色泽在6 h内均无明显改变,室温下放置的配伍液6 h时细菌内毒素检查也符合规定。与左氧氟沙星、哌拉西林钠、头孢呋辛钠、克林霉素、阿昔洛韦、氨曲南、头孢唑啉钠配伍后6 h内相对百分含量均>90%;与头孢哌酮钠配伍含量下降最大,样品液由浅黄色变成深黄色。结论国产醋酸钠林格液与左氧氟沙星、哌拉西林钠、头孢呋辛钠、克林霉素、阿昔洛韦、氨曲南、头孢唑啉钠可配伍使用,不宜与头孢哌酮钠配伍。Objective To observe the stabilities of domestic Ringer＇s acetate injection mixing with 8 antibiotics. Methods The content changing in 6h of the main content- curcumol in mixed fluid , its value of pH, quantity of motes and bacterial endotoxin were detected by using t he method of ultra-violet spectrophotometry, etc, and to observe the appearance of the mixed fluid. Results The mixed fluid produced neither gas nor sediment; the value of pH, quantity of motes and colour did not change markedly in 6h; the detecting of bacterial endotoxin of the mixed fluid laying up indoors in 6h was suitable after mixing with each drug of 8 antibiotic s respectivel y. The percentage of each quantity of the mix ture was more than 90% after domestic Ringer＇s acetate injection was mixed respectively with levofloxacin, piperacillin sodium, cefuroxime sodium, clindamycin, acyclovir, aztreonam and cephazolin sodium for 6h; the content reduced mostly when domestic Ringer＇s acetate injection mixed with cefoperazone sodium and the fluid changed from light yellow to dark yellow. Conclusion Domestic Ringer＇s acetate injection can be used mixing with levofloxacin, piperacillin sodium, cefuroxime sodium, clindamycin, acyclovir, aztreonam and cephazolin sodium; but it can not be used together with cefoperazone sodium.

关 键 词：国产醋酸钠林格液 配伍稳定性 抗菌药物 

分 类 号：R927.11[医药卫生—药学] R942