P63阳性基底细胞在前列腺切除术后尿道再上皮化中的作用  

The role of P63 postive basal cell in re-epithelialization of prostatic urethra after resection of prostate

作　　者：刘旋[1,2] 孙兆林[2] 

机构地区：[1]遵义医学院,贵州遵义563000 [2]贵州省人民医院泌尿外科,贵州贵阳550000

出　　处：《川北医学院学报》2015年第2期160-162,共3页Journal of North Sichuan Medical College

基　　金：国家自然科学基金(81260119);贵州省科技厅基金(黔科合LS[2011]020);贵州省科技厅基金(黔科合SZ字2012[3077];黔科合SY字2011[3024];黔科合人才团队2012[4013])资助

摘　　要：目的:探讨前列腺切除术后P63阳性基底细胞在前列腺部尿道上皮修复过程中的作用。方法:15只老年家犬行前列腺增生切除术,术后第3、7、14天取材行HE染色和免疫组织化学染色分别观察前列腺部尿道上皮修复过程和P63蛋白表达水平。结果:术后3 d手术创面偶见P63阳性细胞;术后7 d可见片状P63阳性细胞,且这些细胞与残余前列腺组织相连续;术后14 d可见新生尿道上皮基底层细胞阳性表达P63。结论:残余前列腺组织是BPH术后尿道再上皮化的重要组织,而位于基底层的P63阳性细胞可能是这一修复过程的源细胞之一。Objective：To evaluate the role of P63 postive basal cell in re-epithelialization of prostatic urethra after resection of the prostate） . Methods：15 older male dogs were treated with resection of the prostate. Specimens of the residual wounds were taken at days 3, 7 and 14 postoperatively to evaluate the expression level of P63 and with HE and immunohistochemical staining. Results：P63 positive cells were detected occasionally in the wounds three days after surgery. At days 7, P63 postive cells appeared lamellar distri-bution connecting with remaining prostatic tissue and at days 14, P63 positive expression was observed in basal cells of newborn urothe-lium. Coclusion：The remaining prostatic tissue plays a great role in re-epithelialization of prostatic urethra after TmLRP and P63 pos-tive cells of basal lamina may be one of the origins of cells for the process.

关 键 词：前列腺切除术 P63 尿路上皮 再上皮化 

分 类 号：R699.8[医药卫生—泌尿科学]