自拟清热利湿方治疗膝骨性关节炎50例疗效观察  

Clinical Observation of 50 Knee Osteoarthritis Patients Treated by Self Prescription for Clearing Heat and Dampness

作　　者：许球祥 伍艳阳[1] 

机构地区：[1]广东省惠州市第三人民医院,广东惠州516002

出　　处：《云南中医中药杂志》2015年第4期50-52,共3页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

摘　　要：目的观察自拟清热利湿方治疗湿热下注型膝骨性关节炎的临床效果。方法选取符合标准的膝骨性关节炎患者100例,随机分为2组,每组50例。对照组给予美洛昔康口服联合关节内注射玻璃酸钠治疗,观察组给予清热利湿中药方,分析2组西医、中医疗效及副作用。结果 (1)治疗组和对照组治疗后2周、治疗后2月关节僵硬、关节疼痛、日常活动以及综合评分的分值均较治疗前下降,差异均有统计学意义(P<0.01);对照组治疗2月后各WOMAC指数分值均较治疗2周后上升,差异有统计学意义(P<0.05);治疗后2周、2个月2组间各WOMAC指数分值比较,治疗组均低于对照组(P<0.05)。(2)治疗后2组中医证候积分和症状、体征分级量化积分均较治疗前有所下降(P<0.01);治疗后各时间点治疗组中医证候积分和症状、体征分级量化积分均较对照组低,差异有显著统计学意义(P<0.01)。(3)2组均无明显不良反应出现。结论自拟清热利湿方剂治疗湿热下注型膝骨性关节炎近期和远期效果好,无明显不良反应,值得在临床上应用。Objective ：To study the clinical effect of self - made prescription for clearing heat and dampness on the treatment of knee osteoarthritis patients with dampheat downward flow type. Methods ：100 patients were randomly divided into two groups,50 patients per group. The control group was given oral Meloxicam plus articular injection while the observation group was given the prescription for clearing heat and dampness. The curative effects and side effects of the two groups were analyzed. Results：The joint stiffness,joint pain,daily activities and comprehensive scores of the patients decreased after two - week and two - month treatment and the differences were statistical- ly significant（ P 〈0. 01 ）. WOMAC index scores of the control group increased after the two - month treatment when compared with the two - week treatment and the difference was statistically significant （P 〈 0. 05 ）. When compared with each WOMAC index scores of the two groups after the two - week and two - month treatment, the score value of the treatment group were lower than that of the control group（ P 〈 0. 05 ）. The TCM symptom scores and symptoms and the grading quantitative integral of physical signs of the two groups decreased after the treatment（ P 〈 0. 01 ）. The TCM symptom scores and symptoms and the grading quantitative integral of physical signs of the treatment group at each time point were lower than those of the control group after the treatment and the difference was statistically significant（ P 〈0.01 ）. The two groups had no significant adverse reactions. Conclusion： The self - made prescription for clearing heat and dampness has a good short - term and long - term effect on the treatment of knee osteoarthritis patients with damp - heat downward flow type, no significant ad- verse reactions, worthy of clinical application.

关 键 词：清热利湿方 湿热下注 膝骨性关节炎 

分 类 号：R255.6[医药卫生—中医内科学]