Changing Grains for the Prevention and Treatment of Kashin-Beck Disease in Children: a Meta-analysis  

作　　者：HAN Jing YU Fang Fang CHANG Zai Ping YANG Bo QU Cheng Juan ZHOU Tian Tian LIU Rui Yu GUO Xiong 

机构地区：[1]College of Public Health, Health Science Center, Xi’an Jiaotong University [2]Department of Surgery, The Second Hospital of Weinan City [3]Department of Laboratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University [4]Department of Applied Physics, University of Eastern Finland [5]Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University

出　　处：《Biomedical and Environmental Sciences》2015年第4期308-311,共4页生物医学与环境科学（英文版）

基　　金：supported by the National Natural Scientific Foundation of China(No.81402639,81472924,81101337)

摘　　要：To evaluate the efficacy of changing grains on the prevention and treatment of Kashin-Beck Disease （KBD） in children, community-based trials were acquired from seven electronic databases （up to July 2014）. As a result, the methodological quality of the six trials that have been included into our analysis was low. The pooled ORs favoring the prevention and treatment effects of changing grains were 0.15 （95% CI： 0.03-0.70） and 2.13 （95% CI： 1.44-3.16） respectively by meta-analysis. Subgroup analysis demonstrated the pooled OR favoring treatment effect of exchanging grains rather than drying grains both compared with endemic grains. The results showed that changing grains had obvious effects on the prevention and treatment of KBD in children. However, the evidences were limited by the potential biases and confounders. Large and well-designed trials are still needed.To evaluate the efficacy of changing grains on the prevention and treatment of Kashin-Beck Disease （KBD） in children, community-based trials were acquired from seven electronic databases （up to July 2014）. As a result, the methodological quality of the six trials that have been included into our analysis was low. The pooled ORs favoring the prevention and treatment effects of changing grains were 0.15 （95% CI： 0.03-0.70） and 2.13 （95% CI： 1.44-3.16） respectively by meta-analysis. Subgroup analysis demonstrated the pooled OR favoring treatment effect of exchanging grains rather than drying grains both compared with endemic grains. The results showed that changing grains had obvious effects on the prevention and treatment of KBD in children. However, the evidences were limited by the potential biases and confounders. Large and well-designed trials are still needed.

关 键 词：KBD Changing Grains for the Prevention and Treatment of Kashin-Beck Disease in Children META 

分 类 号：R726.8[医药卫生—儿科]