HIV治愈:潜伏HIV的清除及其策略  

HIV cure: latent HIV eradication and strategies

作　　者：刘叔文[1] 潘晓彦[1] 赵伟[1] 

机构地区：[1]南方医科大学药学院,广东广州510515

出　　处：《遵义医学院学报》2015年第2期105-110,共6页Journal of Zunyi Medical University

摘　　要：HIV的感染造成机体免疫系统损害,最终引发艾滋病(AIDS),导致全球每年数百万人死于HIV感染引发的肿瘤及感染。高效抗逆转录病毒疗法(HAART)应用于早期感染的患者,可有效抑制HIV的感染,从而避免病毒血症的暴发。但HIV初次感染的不可察觉性和潜伏期,给HIV的预防及治疗带来非常大的难度。除此之外,HIV的整合后潜伏目前,被认为是实现HIV治愈最大的障碍。本文就如何将整合后潜伏的病毒从机体彻底清除,从而实现HIV的根本治愈,并对近年来相关研究的进展进行综述。Millions of people died from cancers and infection caused by immune system damage induced by HIV infection every year in the world. Viremia can be controlled at early stage, but obstacle brought by its unob- servable and latent characteristic hindered HIV prevention and treatment. Currently, the post -integration laten- cy was the biggest barrier to HIV cure. Here, an overview of latent HIV investigation and development to HIV sterilized cure focusing on latent HIV eradication was presented.

关 键 词：潜伏HIV 激活剂 治疗策略 潜伏感染模型 

分 类 号：R446.1[医药卫生—诊断学]