血必净对小儿严重脓毒症凝血功能及预后的影响  

The influence of Xuebijing injection on coagulation function and prognosis in children severe sepsis

作　　者：曾嵘[1] 石明芳[1] 

机构地区：[1]宜宾市第一人民医院儿科,四川宜宾644000

出　　处：《西部医学》2015年第5期776-778,共3页Medical Journal of West China

摘　　要：目的探讨血必净对小儿严重脓毒症凝血功能及预后的影响。方法将64例严重脓毒症患儿随机分为治疗组和对照组各32例,两组均予以抗感染、保护脏器功能、营养支持等对症治疗,在此基础上治疗组加用血必净治疗。两组患儿分别于治疗前和治疗7天后检测血小板(PLT)计数、D-二聚体(D-dimer)及凝血四项,比较住PICU时间、急性生理与慢性健康状况评分(APACHEⅡ评分)及病死率。结果患儿经治疗后,治疗组PLT、D-dimer及凝血四项较治疗前有明显改善,差异均有统计学意义(P<0.01);治疗组PLT、FIB和PT高于对照组,治疗组D-dimer、APTT和TT低于对照组,差异均有统计学意义(P<0.01);治疗组APACHEⅡ评分低于对照组、住PICU时间短于对照组及其病死率低于对照组,差异均有统计学意义(P<0.05)。结论血必净能够纠正严重脓毒症患儿凝血功能紊乱,改善患儿的病情,阻断疾病的发展恶化,并且能够缩短住PICU时间,降低病死率,改善预后。Objective To explore the influence of xuebijing injection on coagulation function and prognosis in chil- dren severe sepsis. Methods 64 children with severe sepsis were divided into treatment group and control group. Each group had 32 children. Both of two groups were treated with anti-infection, viscera function protection, nutritional sup- port and other therapies. Besides,treatment group was treated with xuebijing injection. Then standard platelets, D-dimer and coagulopathy tests were detected. The coagulation indexes before and after the treatment,time in PICU,acute physi- ology and chronic health evaluation （APACHE]I score） and case-fatality rate were observed. Results After treatment, PLT, D-dimer and the blood coagulation indexes of children with severe sepsis in the treatment group were significantly improved. This difference had statistical significance（P〈0.01）. PLT, FIB and PT in the treatment group are higher than those in the control group. D-dimer, APTT and TT in the treatment group were lower than those in the control group. There was statistical significance （P〈0.01）. APACHE Ⅱ score of the treatment group was lower than that of the control group. Time in PICU of the treatment group was shorter than that of the control group. The case-fatality rate of the treatment group was lower than that of the control group. Conclusion Xuebijing has important clinical significance because it can improve children with severe sepsis in coagulation disorders, reduce case-fatality rate and improve prognosis.

关 键 词：血必净 严重脓毒症 凝血功能 儿童 

分 类 号：R720.5[医药卫生—儿科]