阿莫西林克拉维酸钾联合糜蛋白酶治疗儿童急性化脓性扁桃体炎疗效观察  

Effects of amoxicillin and clavulanate potassium combined with chymotrypsin on children with acute suppurative tonsillitis

作　　者：乔勇[1] 余霞辉[1] 邓骥[1] 邱有波[1] 罗扬[1] 

机构地区：[1]四川省崇州市人民医院儿科,四川崇州611230

出　　处：《实用医院临床杂志》2015年第3期97-99,共3页Practical Journal of Clinical Medicine

基　　金：四川省成都市科技局科技惠民项目(编号:2013-HM01-3-00004-SF)

摘　　要：目的：探讨阿莫西林克拉维酸钾联合糜蛋白酶治疗儿童急性化脓性扁桃体炎的疗效。方法采用随机数字表法将122例化脓性扁桃体炎患儿分为治疗组（62例）和对照组（60例），对照组单用阿莫西林克拉维酸钾，治疗组在此基础上加用糜蛋白酶治疗，疗程均为7～10 d。比较两组治疗后主要症状体征改善时间、总有效率和不良反应。结果治疗组体温恢复正常、咽痛缓解、咽部充血消退、扁桃体肿大减轻、分泌物消退等时间均明显优于对照组，总有效率（96．77％）高于对照组（85．0％），差异均有统计学意义（ P＜0．05）；两组不良反应发生率差异无统计学意义（ P＞0．05）。结论阿莫西林克拉维酸钾联合糜蛋白酶治疗儿童急性化脓性扁桃体炎，能缩短症状持续时间，提高治疗有效率，使用安全，值得临床推广应用。Objective To explore the effects of amoxicillin and clavulanate potassium combined with chymotrypsin on children with acute suppurative tonsillitis .Methods One hundred and twenty-two children with acute suppurative tonsillitis were randomly di-vided into treatment group （ n =62 ） and control group （ n =60 ） .The treatment group was administrated with amoxicillin and clavu-lanate potassium combined with chymotrypsin while the control group was administrated with amoxicillin and clavulanate potassium on -ly.Two groups were treated for 7 to 10 days.The improvement time of main symptom and the clinical effect were compared between the two groups.Results The times of temperature returning to normal ,angina relieve,pharyngeal hyperaemia fading ,swollen tonsils relieve and discharge extinction in the treatment group were significantly shorter than that in the control group （ P＜0.05 ） .The total efficiency in the treatment group（96.77%）was significantly higher than that in the control group （85.0%）（P＜0.05）.There was no significant difference in incidence of adverse reactions between the two groups .Conclusion Amoxicillin and clavulanate potassium combined chy-motrypsin can shorten the duration of symptoms and improve the treatment efficiency in the treatment of children with acute suppurative tonsillitis.

关 键 词：阿莫西林克拉维酸钾 糜蛋白酶 儿童 急性化脓性扁桃体炎 

分 类 号：R725.6[医药卫生—儿科]