大七厘散的质量标准研究  

Study of the Quality Standards of Daqili Powder

作　　者：陈惠玲[1] 胡珊梅[1] 陈洁[1] 李玲玲[1] 黄惠琼[1] 

机构地区：[1]厦门市药品检验所,福建厦门361012

出　　处：《中国药物评价》2015年第2期83-86,共4页Chinese Journal of Drug Evaluation

基　　金：2012年厦门市重大科技项目;项目编号:3502Z20121035

摘　　要：目的：研究大七厘散质量标准。方法：建立大黄、当归、冰片、三七及骨碎补的薄层鉴别项。采用HPLC法对血竭中的主要成分血竭素进行含量测定,供试品溶液以12%磷酸甲醇溶液为溶媒的制备,流动相：乙腈-0.05 mol·L^-1磷酸二氢钠溶液（50∶50）;检测波长440 nm。结果：血竭素在0.774~77.415μg·m L^-1范围内呈良好的线性关系,r=0.9999。加样回收率为100.2%,相对标准偏差（RSD）=1.8%（n=9）。结论：本法分离效果好,准确可靠,适用于大七厘散的质量控制。Objective：To establish quality control for Daqili Powder.Methods： Rhei Radix et Rhizoma, Angelicae sinensis Radix, Borneolum Syntheticum,Notoginseng Radix et Rhizoma, Drynariae Rhizoma in Daqili Powder were identified by TLC,and draorhodin was determined by HPLC.Test solution was made with 12%phosphoric acid in methanol,Use a mixture of acetonitrile and 0.05 mol· L^-1 so-dium dihydrogen phosphate solution （50∶50） as the mobile phase.As detector a spectrophotometer set at 440 nm.Results：The calibration curves were linear within the range of 0.774~77.415 μg· mL^-1 （ r=0.9999 ）.The average recovery was 100.2% with RSD was 1.8%（ n=9）.Conclusion：The method is sensitive and accurate,and it is suitable for the quality control of Daqili Powder.

关 键 词：大七厘散 血竭素 大黄 当归 冰片 三七 骨碎补 质量标准 

分 类 号：R286.0[医药卫生—中药学] O657.7[医药卫生—中医学]