血脂异常不同证候间患者血浆ONOO^-、D-二聚体特点及其与血脂指标典型相关性分析  

Canonical correlation analysis of blood lipids and TCM syndrome and study on the characteristics of plasma ONOO^- and D-dimer in dyslipidemia patients

作　　者：陈婧[1] 杨惠民[1] 叶超[1] 薛晓琳[2] 

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学基础医学院,北京100029

出　　处：《中华中医药杂志》2015年第5期1704-1707,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：北京中医药大学基本科研业务费(自主选题类)在读研究生资助项目(No.2014-JYBZZ-XS-135)~~

摘　　要：目的:探讨不同证候间血脂异常患者血浆过氧亚硝基阴离子(ONOO-)、D-二聚体特点、证候与血脂指标的典型相关性。方法:采用流行病学横断面调查的方法,测定116例不同证候血脂异常患者相关指标,分析不同证候患者血浆ONOO-、D-二聚体特点,对血脂指标与中医证候积分进行典型相关分析。结果:1痰浊阻遏证血脂异常患者血浆ONOO-高于脾肾阳虚证患者,D-二聚体低于脾肾阳虚证患者(P<0.05);2TC和中医证候间有典型相关性、痰浊阻遏证和血脂指标间具有典型相关性。结论:血浆ONOO-及D-二聚体结合临床症状有可能成为评价血脂异常患者中医证候程度的参考指标之一。TC能更敏感反映中医证候程度,而痰浊阻遏证的严重程度与血脂指标的关系更加密切。血脂指标与证候积分的典型相关性为中医药防治血脂异常提供了依据。Objective： Observe the canonical correlation analysis of blood lipids and TCM syndrome and study on the characteristics of plasma ONOO- and D-dimer in dyslipidemia patients. Methods： Cross-sectional epidemiological field survey was adopted to collect the main clinical data of 116 dyslipidemia patients. The characteristics of plasma ONOO- and D-dimer were compared based on different types of TCM syndrome. The canonical correlation relationship between TCM syndrome score and blood lipids were analyzed. Results： （1）Comparing with the plasma ONOO-, the numerical value of spleen and kidney yang deficiency syndrome is lower than phlegm-dampness retention syndrome in dyslipidemia patients and there were significant differences （P〈0.05）. Comparing with the D-dimer, the numerical value of spleen and kidney yang deficiency syndrome was higher than phlegm-dampness retention syndrome in dyslipidemia patients and there were significant differences （P〈0.05）. （2）The results of canonical correlation analysis revealed that there were canonical correlation between total cholesterol （TC） and TCM syndrome, phlegm-dampness retention syndrome and blood lipids. Conclusion： The plasma ONOO- and D-dimer combined with symptoms may be one of reference indexes in evaluating the degree of TCM syndrome in dyslipidemia patients. TC can sensitively react the degree of TCM syndromes. The relationship between blood lipids and the degree of phlegm-dampness retention syndrome is closely. The canonical correlation between TCM syndrome score and blood lipids may provide evidence for treating and preventing dyslipidemia by TCM means.

关 键 词：血脂异常 中医证候 血脂指标 典型相关分析 过氧亚硝基阴离子 D-二聚体 

分 类 号：R259[医药卫生—中西医结合]