芍药甘草汤镇痛作用研究及镇痛效果与配伍比例相关性分析（英文）  

Analgesic effects of Shaoyao Gancao Tang and the correlation between analgesic effects and compatibility proportion

作　　者：汪萌[1] 闫永红[1] 邹慧琴[1] 朱广伟[1] 彭莲[1] 李佳慧[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中华中医药杂志》2015年第5期1767-1773,共7页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：National Natural Science Foundation of China(No.81403054)~~

摘　　要：目的:将白芍的4种药效组分、甘草的5种药效组分根据芍药甘草汤中的药效组分实测值进行配伍,配伍成芍药甘草汤组分中药研究镇痛作用。方法:分别将昆明种小鼠随机分为空白组、阳性对照组(阿司匹林10mg/kg)、芍药甘草汤组(10,20,30mg/kg),口服给药观察芍药甘草汤的镇痛效果。结果:芍药甘草汤组分中药显示出显著的镇痛效果,药效组分配伍比例相同时镇痛效果相似,药效组分配伍比例不同时镇痛效果有显著差异。结论:药效组分配伍比例相同时代表相同的组分中药,因此具有相同的治疗作用;药效组分配伍比例不同时候,代表不同的组分中药,因此具有不同的治疗作用。Objective： To use the combination of nine herbal extracts as an alternative medicine of Shaoyao Gancao Tang （SGT） and analyze the correlation between analgesic effects and compatibility proportion. Methods： Kunming rats were randomly divided into control group, Aspirin group, and SGT group. Aspirin （10mg/kg）, SGT （10, 20, 30mg/kg） were administered by oral gavage. Results： In hot plate test, SGT- Ⅰ and SGT- Ⅱ at 10, 20 and 30mg/kg doses produced significant analgesic effects in 60^th, 90^th and 120^th minute （P〈0.05, compared with control values）. SGT- Ⅲ at 10mg/kg doses had no analgesic effect in both 60^th and 120^th minutes and it also had no analgesic effects at 20mg/kg in 120^th minute （compared with control values）. In acetic acid writhing test, SGT- Ⅰ and SGT- Ⅱ produced significant analgesic effects at 10, 20 and 30mg/kg doses （P〈0.05, compared with control values）. SGT-Ⅲ had analgesic effects only at 30mg/kg （P〈0.05, compared with control values）. There was a dose- dependent relationship between analgesic effects and the administered dosage of SGT- Ⅰ and SGT- Ⅱ at 10, 20 and 30mg/kg doses in 60^th, 90^th and 120^th minutes in both hot plate test and acetic acid writhing test. Conclusion： In this study, we have shown that SGT- Ⅰ, SGT- Ⅱ and SGT- Ⅲ produced analgesic effect. SGT- Ⅰ and SGT- Ⅱ have the same compatibility proportion and they has produced an equal analgesic effect. SGT- Ⅱ and SGT- Ⅲ have different compatibility proportion and they producs different analgesic effect. The study indicates that the combination of nine herbal extracts can be used as an alternative medicine of SGT.

关 键 词：芍药甘草汤 药效组分 镇痛作用 配伍比例 

分 类 号：R285.5[医药卫生—中药学]