金银花化学成分研究  

Study on Chemical Constituents of Lonicera japonica Bud

作　　者：姜南辉[1] 

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中药材》2015年第2期315-317,共3页Journal of Chinese Medicinal Materials

摘　　要：目的:研究金银花的化学成分。方法:采用硅胶柱色谱、凝胶柱色谱、反相ODS柱色谱等多种手段进行分离纯化,通过理化性质和MS、1H-NMR和13C-NMR等谱学技术进行结构鉴定。结果:从金银花中分离得到8个化合物,分别鉴定为:原儿茶酸(1)、5-羟基-7,3',4'-三甲氧基黄酮(2)、金丝桃苷(3)、4-羟基桂皮酸(4)、咖啡酸乙酯(5)、洋芹素(6)、5-羟基-6,7,8,4'-四甲氧基黄酮(7)、月桂酸乙酯(8)。结论:其中,化合物5、7、8为首次从该属植物中分离得到。Objective ： To study the chemical constituents of Lonicera japonica bud. Methods ： The compounds were isolated and re- peatedly purified by silica gel column chromatography, gel column chromatography and ODS chromatography. The structures were eluci- dated by physicochemical properties, MS and NMR. Results ： Eight compounds were isolated and their structures were identified as proto- catechuic acid （ 1 ） ,5-hydroxy-7,3＇, 4＇-trimethoxyflavone （ 2）, hyperoside （ 3 ） ,4-hydroxycinnamic acid （4）, ethyl caffeate （ 5 ）, apigenin （6） ,5-hydroxy-6,7,8,4＇-tetramethoxyflavone（7 ）, and ethyl laurate （8）. Conclusion：Compounds 5,7 and 8 are obtained from this ge- nus for the first time.

关 键 词：金银花 化学成分 结构鉴定 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]