生物分子相互作用动力学的表面等离子体共振研究方法  

Surface Plasmon Resonance Methodology for Interaction Kinetics of Biomolecules

作　　者：王霄[1,2] 许吉英[1] 陈义[1,2,3] 

机构地区：[1]中国科学院化学研究所活体分析化学院重点实验室,北京100190 [2]中国科学院大学,北京100049 [3]北京分子科学国家实验室,北京100190

出　　处：《化学进展》2015年第5期550-558,共9页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21235007;21135006);中国科学院知识创新工程重要方向项目(No.KJCX2-EW-N06-01)资助~~

摘　　要：表面等离子体共振及其成像方法以其免标记、可实时动态原位跟踪反应过程而在生物分子相互作用动力学及其常数测定研究中凸显优势,近年来这方面的研究进展迅速,但缺乏必要的总结归纳。为此,本文就这一主题所涉及的关键研究方法与应用进展作简要的归纳分析并展望了该领域的发展前景。Surface plasmon resonance sensing and imaging methods have been developing very fast during recent years, especially in applying to the study of biomolecular interactions and/or recognitions and determination of kinetic and thermodynamic constants. These progresses are broadly interesting but remain short of reviewing. This paper is thus designed and dedicated to the methodization of the very recent, critical developments in the study of molecular reaction kinetics and measure of their constants. In the end, their prospect is given, in addition to a brief summary of other research progresses.

关 键 词：表面等离子体共振 传感与成像 生物分子相互作用 动力学分析 

分 类 号：O651[理学—分析化学]