Isolation and structural identification of two bioactive phenazines from Streptomyces griseoluteus P510  

灰藤黄链霉菌P510中两个活性吩嗪类物质的分离及结构鉴定（英文）

作　　者：罗勤 胡洪波 彭华松 张雪洪 王威 

机构地区：[1]State Key Laboratory of Microbial Metabolism, School of Life Science and Biotechnology, Shanghai Jiao Tong University

出　　处：《Chinese Journal of Chemical Engineering》2015年第4期699-703,共5页中国化学工程学报（英文版）

基　　金：Supported by the National High Technology Research and Development Program of China(2012AA022107);the National Basic Research Program of China(2012CB722105);the National Natural Science Foundation of China(20706037);the Ph.D.Programs Foundation of Ministry of Education of China(20090073110052)

摘　　要：Phenazine antibiotics phenazine-l-carboxylic acid （PCA） and l-hydroxyphenazine （1-OH-PHZ） were purified from culture broth and mycelia ofStreptomyces griseoluteus P510, Both PCA and 1 -OH-PHZ exhibit strong antifun- gal activity against six plant pathogens, especially Fusarium oxysporium, with minimal inhibition concentrations less than I and 2/ag, ml- 1 for PCA and 1-OH-PHZ, respectively, The presence of PCA and 1 -OH-PHZ indicates that S. griseoluteus PSlO can be used as a potential source of pesticides,Phenazine antibiotics phenazine-1-carboxylic acid(PCA)and 1-hydroxyphenazine(1-OH-PHZ)were purified from culture broth and mycelia of Streptomyces griseoluteus P510.Both PCA and 1-OH-PHZ exhibit strong antifungal activity against six plant pathogens,especially Fusarium oxysporium,with minimal inhibition concentrations less than 1 and 2μg·ml-1for PCA and 1-OH-PHZ,respectively.The presence of PCA and 1-OH-PHZ indicates that S.griseoluteus P510 can be used as a potential source of pesticides.

关 键 词：Streptomyces griseoluteus P510Phenazine antibioticPhenazine-1-carboxylic acidl-Hydroxyphenazine 

分 类 号：TQ465[化学工程—制药化工]