全血白细胞计数水平与高血压风险的关系  

Relationship between leukocyte count and risk of hypertension

作　　者：郗璐[1] 郝永臣[1] 刘静[1] 王薇[1] 王淼[1] 齐玥[1] 赵帆[1] 解武祥[1] 李岩[1] 刘军[1] 孙佳艺[1] 秦兰萍[1] 赵冬[1] 

机构地区：[1]首都医科大学附属北京安贞医院 北京市心肺血管疾病研究所流行病研究室,100029

出　　处：《中华心血管病杂志》2015年第4期312-318,共7页Chinese Journal of Cardiology

基　　金：国家重点基础研究发展计划（2012CB517806）

摘　　要：目的 探讨全血白细胞计数水平与血压水平、高血压患病以及高血压15年累积发生风险的关系.方法 入选“中国多省市队列研究”人群中1992和2007年参加心血管疾病危险因素调查的研究对象4 188名.对白细胞计数水平与血压水平和高血压患病的关系进行横断面分析.对基线无高血压的2 954名研究对象进行白细胞计数水平与血压水平变化和高血压发生风险的前瞻性分析,白细胞计数水平与血压水平变化的关联分析采用Spearman秩相关和多重线性回归,白细胞计数水平与高血压发生风险的关联分析采用多因素logistic回归.结果 （1）横断面研究显示,白细胞计数水平与收缩压水平（r =0.208,P＜0.001）和舒张压水平（r=0.154,P＜0.001）均呈正相关.多重线性回归分析显示,白细胞计数每增加1×10^9/L,收缩压水平增加1.41 mmHg（1 mmHg =0.133 kPa）（95％ CI：1.20 ～ 1.63 mmHg,P＜0.001）,舒张压水平增加0.63 mmHg （95％ CI：0.51 ～0.76 mmHg,P＜0.001）.多因素logistic回归分析显示白细胞计数每增加1×10^9/L,高血压患病风险增加15％（OR：1.15,95％ CI：1.12 ～1.19,P＜0.001）.（2）在15年的队列随访过程中,47.2％（1 394/2 954）的研究对象发生高血压.Spearman秩相关分析显示,基线白细胞计数水平与收缩压水平增加量（r=0.062,P=0.003）和舒张压水平增加量（r=0.102,P＜0.001）均呈正相关.多重线性回归分析显示,基线白细胞计数每增加1×10^9/L,收缩压水平增加1.03 mmHg （95％ CI：0.74～1.32 mmHg,P＜0.001）,舒张压水平增加0.64 mmHg（95％ CI：0.48 ～0.80 mmHg,P＜0.001）.多因素logistic回归分析显示,白细胞计数每增加1×10^9/L,高血压的发生风险增加9％（OR：1.09,95％ CI：1.06～ 1.13,P＜0.001）.结论 白细胞计数水平升高与高血压的患病和发生风险均有关,提示慢性炎症可能参与高血压的发生和发展.Objective To observe the association between the leukocyte count and blood pressure value and hypertension risk in a Chinese community-based population.Methods A total of 4 188 participants who took part in the baseline examination in 1992 and the follow-up survey in 2007 from the Chinese Multi-Provincial Cohort Study were included in this study.The relationship of leukocyte and blood pressure value and hypertension risk were evaluated by cross-sectional analyses.The prospective association between baseline leukocyte count and blood pressure changes and risk of hypertension were analyzed in 2 954 normotensive individuals at baseline examination.The associations between leukocyte count and blood pressure was evaluated with Spearman＆#39;s rank correlation analyses and linear regression models,and the associations between leukocyte count and risk of hypertension was evaluated with logistic regression models.Results （1） The cross-sectional study results showed that the correlation coefficient of leukocyte count and systolic blood pressure and diastolic blood pressure was 0.208 and 0.154 （both P 〈 0.001）,respectively.Multiple linear regression analyses showed that every 1 × 10^9/L increment in leukocyte count was associated with 1.41 mmHg（1 mmHg =0.133 kPa）systolic blood pressure increase （95% CI：1.20-1.63 mmHg,P 〈0.001） and 0.63 mmHg diastolic blood pressure increase （95% CI：0.51-0.76 mmHg,P 〈 0.001）.Multivariable logistic regression analyses showed that every 1 × 10^9/L increment in leukocyte count was associated with a 15% increased risk of hypertension （OR：1.15,95% CI：1.12-1.19,P 〈0.001）.（2） During 15 years of follow-up,47.2% （1 394/2 954） normotensive individuals progressed to hypertension.Spearman＆#39;s rank correlation analyses showed that,the correlation coefficient of leukocyte count and systolic blood pressure change and diastolic blood pressure change was 0.062 （P =0.003） and 0.102 （P〈0.001）,respectively.Multiple linear regression analyses show

关 键 词：白细胞计数 高血压 危险 

分 类 号：R544.1[医药卫生—心血管疾病]