阿尔茨海默病β-淀粉样蛋白的近红外荧光探针研究进展  

Progress in the study of near-infrared fluorescent probes for the detection of β-amyloid deposition in Alzheimer's disease

作　　者：杜蕾[1] 冯海威 李玉艳[1] 

机构地区：[1]中国药科大学药学院,江苏南京210009

出　　处：《药学学报》2015年第5期528-534,共7页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金青年基金面上项目(81102317)

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是最常见的老年认知障碍疾病。随着社会老龄化越来越严重,AD给患者和社会造成巨大的负担。大脑中Aβ-淀粉样蛋白沉积是AD患者早期发现、跟踪、预防和治疗的特异性生物标志物。与正电子发射断层扫描及单光子发射计算机断层显像的核成像相比,近红外荧光成像具有高灵敏度、无创、安全、价廉等优点。因此用于近红外荧光成像的小分子探针成为目前的热点研究领域。本文综述了标记Aβ-淀粉样蛋白沉积的近红外荧光小分子探针最新的研究进展。Alzheimer＇s disease （AD） is the most common cause of cognitive impairment in older With the aging of society is more and more serious, AD caused great burden to patients and society. people. A β- is a classical biomarker of AD, which has been widely used in clinical diagnosis of AD patients. Compared with positron emission tomography （PET） and single photon emission computed tomography （SPECT）, near infrared fluorescence imaging has many advantages including highly sensitive, non-invasive, safety and inexpensive. Therefore, many research groups have focused on developing the molecular probes of near-infrared fluorescence （NIRF） imaging. In this article, we will review the progress of the probes of N1RF.

关 键 词：阿尔茨海默病 Β-淀粉样蛋白 近红外荧光探针 

分 类 号：R916[医药卫生—药学]