超排卵全程应用225U促黄体生成素对取卵及胚胎移植日血清血管内皮生长因子水平的影响  

Whole Course 225 U Recombinant Luteinizing Hormone Application can Decrease Serum Vascular Endothelial Growth Factor Level on Oocyte Pick Up and Embryo Transfer Day

作　　者：袁媛[1] 苗本郁[1] 麦庆云[1] 徐艳文[1] 周灿权[1] 

机构地区：[1]中山大学附属第一医院生殖医学中心//广东省生殖医学重点实验室,广东广州510080

出　　处：《中山大学学报（医学科学版）》2015年第2期227-230,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广州市科技计划项目(201300000097);广东省生殖医学站实验室建设项目(2012A061400003)

摘　　要：【目的】探讨促黄体生成素在控制性超排卵中降低血清血管内皮生长因子水平的有效性。【方法】20例在超排卵全程添加225 U促黄体生成素(实验组)同50例未添加患者(对照组)比较超排卵启动日血清血管内皮生长因子水平,人绒毛膜激素注射日、取卵日及胚胎移植日血清血管内皮生长因子较启动日的升高水平。【结果】试验组及对照组启动日血清血管内皮生长因子水平及人绒毛膜激素注射日血清血管内皮生长因子较启动日的升高水平差异不具有统计学意义;试验组取卵日(P=0.017)及胚胎移植日血清血管内皮生长因子较启动日的升高水平(P=0.009)同对照组相比,差异具有统计学意义。【结论】225 U促黄体生成素在超排卵全程应用可有效降低取卵及胚胎移植日血清血管内皮生长因子水平。[Objective] To investigate the effectiveness of luteinizing hormone （LH） in decreasing serum vascular endothelial growth factor （VEGF） level during controlled ovarian hyperstimulation （COH）. [Method] Comparing serum VEGF level on COH starting day and comparing elevated serum VEGF level on human chorionic gonadotropin （HCG） administration day, oocyte pick up （OPU） day and embryo transfer （ET） day between 20 patients with whole course 225 U LH application and 50 patients without during COH. [ Results] Serum VEGF level on starting day and serum VEGF level elevated on HCG day was comparable of two groups. However, serum VEGF level elevated on OPU day （P = 0.017） and ET day （P = 0.009） of study group were significantly lower than control group. [ Conclusion ] Whole course 225 U LH application during C OH can effectively decrease serum VEGF level on OPU and ET day.

关 键 词：超排卵 促黄体生成素 血管内皮生长因子 

分 类 号：R711.6[医药卫生—妇产科学]