抗骨质疏松治疗对原发性骨质疏松症患者骨密度及骨折率的影响  

The effect of anti-osteoporosis therapy on bone mineral density and fracture rate in patients with primary osteoporosis

作　　者：殷晓雪[1] 宋纯理[1] 杜国红[1] 

机构地区：[1]北京大学第三医院骨科,北京100191

出　　处：《中国骨质疏松杂志》2015年第4期421-423,共3页Chinese Journal of Osteoporosis

摘　　要：目的通过对132例原发性骨质疏松症患者抗骨质疏松规范治疗1年前后的对比,明确骨质疏松症早期诊断治疗的意义。方法以我院2011-2012年间门诊诊治的有完整记录的原发性骨质疏松症患者132例为研究对象,给予正规抗骨质疏松治疗1年,对治疗前后每位患者的临床症状[视觉模拟评分(Visual Analogue Score,VAS),双能X线吸取测量法(Dual Energy X-ray Absorptiometry,DEXA)测定骨密度(Bone mineral density,BMD)]、骨折发生率进行对比和统计分析。结果 85例(65%)患者首诊时伴随有腰酸背痛腿抽筋等症状,治疗3个月后明显好转,1年后仅少数人遗留轻度的腰酸背疼,与治疗前差异显著;不论是骨密度绝对值还是T值,治疗前后均有显著性差异;132例患者在1年的治疗期间仅有2例发生新发骨折,占所有患者的1.51%。结论正规的抗骨质疏松治疗不仅可以快速显著地改善临床症状,而且可以提高骨密度,并能预防骨折、降低骨折发生率。Objective To illuminate the significance of early diagnosis of osteoporosis by comparison of regular anti-osteoporosis therapy for 132 primary osteoporosis patients before and after treatment.Methods Data of 132 osteoporosis patients who received regular anti-osteoporosis therapy for 1 year in the out-patient of our hospital from 2011 to 2012 were collected.Clinical symptom （ Visual Analogue Score, VAS ） , bone mineral density （ Dual Energy X-ray Absorptiometry, DEXA ） , and the incidence of fractures before and after treatment were compared and statistically analyzed.Results Backache and leg cramps occurred in 85 patients （65%） at initial diagnosis, which were relieved greatly after 3-month treatment.Only few patients remained mild back pain after 1-year therapy.Both absolute value of bone mineral density and the T-score changed significantly after the treatment.Only 2 cases of new fracture occurred during the 1-year treatment in 132 patients （ 1.51%） .Conclusion Regular anti-osteoporosis treatment can not only rapidly relieve the clinical symptoms, but also improve bone mineral density, prevent fractures, and reduce the incidence of fractures.

关 键 词：骨质疏松 骨密度 骨折发生率 

分 类 号：R589[医药卫生—内分泌]