儿童EB病毒感染的实验室诊断  

Laboratory diagnosis of EBV infection in children

作　　者：马展[1] 张泓[1] 

机构地区：[1]上海市儿童医院上海交通大学附属儿童医院检验科,200040

出　　处：《中华检验医学杂志》2015年第4期223-225,共3页Chinese Journal of Laboratory Medicine

摘　　要：EB病毒（EBV）是儿童期感染的重要病原体，除急性或一过性感染外，EBV还有可能引起慢性活动性EBV感染、嗜血淋巴组织增生、淋巴瘤等多种不良预后。因此，EBV感染的实验室诊断对于EBV感染相关疾病诊断、监控和不良预后的控制具有重要意义。当前EBV实验室诊断主要集中在EBV-DNA载量和血清学2个方面，不同的检验项目和标本类型具有不同的临床意义和适用范围，这给检验项目和方法的选择带来了一定的困扰。本文对检测EBV技术的临床价值进行了系统的分析，并对EBV感染的免疫学功能、恶性EBV感染性疾病易感基因检测的临床应用进行了展望。Epstein-Barr virus （EBV） remains one of the most important pathogens in children, which usually causes acute EBV infection, chronic active EBV infection, hemophagocytic lymphohistioeytosis, lymphoma and other cancers. Therefore, effective laboratory diagnosis is of importance in diagnosis, surveillance, and control of EBV-associated disease. Currently, a variety of detection methods have been applied in clinical laboratories and typical diagnostic assays are always focusing on EBV-DNA and serological tests. Different assays vary in different purposes and applications, which seems to be difficult to choose an appropriate technique. This article aims at systematically analyzing clinical significance of these assays and evaluating the immune functions of EBV infection and the detection of susceptibility genes of EBV-related disease.

关 键 词：爱泼斯坦巴尔病毒感染 病毒载量 临床实验室技术 

分 类 号：R725.1[医药卫生—儿科] R446.1[医药卫生—临床医学]