T淋巴细胞上主要离子通道的生理学和药理学研究进展  

The physiological and pharmacological study of major ion channels in T lymphocytes

作　　者：刘国欣[1] 李明春[1] 

机构地区：[1]解放军第401医院药剂科,青岛266000

出　　处：《免疫学杂志》2015年第5期441-445,共5页Immunological Journal

摘　　要：T淋巴细胞是生物体内最重要的免疫细胞之一,在机体免疫系统中发挥着重要作用。它的活化、增殖离不开膜上的离子通道。T淋巴细胞膜上有5种离子通道与它的活性关系密切,它们作为免疫调节过程的潜在靶点发挥重要作用。Ca2+通过Ca2+通道(Ca2+-release activated Ca2+channels,CRAC channels)进入T淋巴细胞作为第二信使参与T淋巴细胞的激活;K+离子通道参与T淋巴细胞的膜电位调节,同时它与Cl-通道(Clswell)共同参与T淋巴细胞的体积调节;TRPM7(transient receptor potential melastatin7)维持T淋巴细胞内Mg2+的平衡。本文扼要回顾了5种离子通道的研究进展,选择性的描述电压门控钾离子通道(KV1.3)以及钙离子依赖型钾离子通道(KCa3.1)离子通道阻滞剂研究进展与药理学意义。T lymphocyte is an important immunocyte, which plays an important role in cellular and humoral immunity. Research has demonstrated that ion channels were vital for T lymphocyte activation and proliferation. There are five distinct types of ion channels comprising a network that performs functions vital for ongoing cellular homeostasis and for T-cell activation. Ca2＋ influx through Ca2＋-release activating Ca2＋ （CRAC） is essential to trigger T lymphocyte activation; K＋ channels contribute to the formation of T lymphocyte membrane potential; Cl- channel （Clswell） and KV1.3 work together functionally in T lymphocyte in the regulation of cellular volume; TRPM7 play a role in Mg2＋ homeostasis. Here we review the recent progress on the five ion channels in T lymphocyte and the blockers of the ion channels-voltage gated potassium channel （KV1.3） and calcium activated potassium channel （KCa3.1）.

关 键 词：T淋巴细胞 K+通道 CRAC通道 CA2+ 

分 类 号：R96[医药卫生—药理学]