维生素D与慢性肾脏病患者的免疫调节功能  

The immune regulation role of vitamin D in chronic kidney disease

作　　者：张倩[1] 陈靖[1] 

机构地区：[1]复旦大学附属华山医院肾脏科,上海200040

出　　处：《肾脏病与透析肾移植杂志》2015年第2期156-159,共4页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：维生素D缺乏在慢性肾脏病患者中很常见,且与患者预后相关。维生素D不仅参与矿物质代谢,也在免疫调节中发挥重要作用。因为尿毒症毒素、营养不良、透析器生物相容性及维生素D甲状旁腺素轴等因素,慢性肾脏病患者往往存在免疫功能失调。本文就维生素D在固有免疫、适应性免疫中的作用展开探讨,着重对维生素D参与调节慢性肾脏病患者的免疫功能方面进行综述。Vitamin D deficiency is common in patients with chronic kidney disease, and is associated with poor prognosis. Vitamin D is not only involved in mineral metabolism, but also plays an important role in immune regulation. Because of uremic toxins, malnutrition, dialyzer biocompatibility, the change of vitamin D and parathyroid hormone axes and other factors, chronic kidney disease patients often have immune dysfunction. This article focused on the role of vitamin D in innate immunity and adaptive immunity, and also reviewed the effects of vitamin D in the regulation of immune function in patients with chronic kidney disease.

关 键 词：慢性肾脏病 维生素D 免疫调节 炎症 

分 类 号：R692[医药卫生—泌尿科学]