肾小球微管状免疫球蛋白沉积  

Immunotactoid glomerulopathy

作　　者：陈浩[1] 朱小东[1] 曾彩虹[1] 

机构地区：[1]南京军区南京总医院肾脏科,国家肾脏疾病临床医学研究中心,全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2015年第2期190-194,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：55岁男性,肾病综合征伴血清肌酐升高,肾外有贫血、低补体血症,肾活检组织学改变为肾小球系膜区及内皮下区域大量PAS强阳性物质沉积,免疫病理示多种免疫球蛋白及补体广泛沉积于肾小球,电镜证实沉积物为排列紊乱的中空管状物。该患者最终诊断为免疫管状肾小球病。55-year-old male presented with nephrotic syndrome, renal dysfunction, anemia and bypocomplementemia for 2 months. Renal biopsy showed strongly PAS-positive in mesangial areas and along GBM. Immunofluerescence indicated glomerular positive staining for IgG, IgA, IgM, C3, κ and λ light chain. Ultrastructral examination showed electron dense deposits in subendothelial regions. On high magnification, the deposits were composed of microtubules with distinct hollow centers and mussy arrangement. His final diagnosis was immunotactoid glomerulopathy.

关 键 词：免疫管状肾小球病 纤维样肾小球肾炎 微管状结构 肾活检 

分 类 号：R692.6[医药卫生—泌尿科学]