四个不同种属动物肢体Ⅱ导联心电图比较  

Comparison of the ECG lead Ⅱ characteristics in four different species of animals

作　　者：谭莹 苏敏 廖伟 史新辉 杨宏博 毛勇 徐红花 师廷川 李勇 那敏 王京昆 

机构地区：[1]云南白药集团创新研发中心,云南省药物研究所,云南省中药和民族药新药创制企业重点实验室,昆明650111

出　　处：《中国实验动物学报》2015年第2期194-198,共5页Acta Laboratorium Animalis Scientia Sinica

摘　　要：目的对比格犬、恒河猴、日本大耳白兔、树鼩四个不同种属实验动物的ECG-II进行分析比较,归纳其ECG-II的特点,旨在为上述动物在安评中的运用提供参考。方法选择成年比格犬、恒河猴、日本大耳白和树鼩,分别对其在清醒状态下的ECG-II进行描记和分析,并对ECG-II各项指标进行测量分析。结果与结论不同种属动物均为窦性心律,在波型方面基本一致,未出现特异性改变,但不同动物在QRS波群和T波形态上具有一定差异;各指标测定结果显示,日本大耳白兔P波、T波振幅和树鼩心率分别小于和快于其他种属动物。Objective The ECG lead II characteristics of Beagle dog, rhesus monkey, Japanese white rabbit and tree shrew were analyzed and summarized to provide reference for drug safety evaluation studies.Methods The ECG lead II of healthy adult Beagle dog, rhesus monkey, Japanese white rabbit and tree shrew were recorded to determine the interval of P, PR, QT （ QTc） , the QRS waves and amplitude of P, R, T waves and the ST shift.Results and Conclusion All the animals had sinus rhythm.All the four species of animals had similar ECG pattern with no particular specific changes, but had some differences of the QRS wave group and T wave.The amplitude of P and T waves in Japanese white rabbit was smaller, and the heart rate of tree shrew was faster than that of the other species of animals.The ECG leadⅡdatabase of the Beagle dog, rhesus monkey, Japanese white rabbit and tree shrew is established.

关 键 词：比格犬 恒河猴 日本大耳白兔 树鼩 心电图 ECG-Ⅱ 

分 类 号：Q95-33[生物学—动物学]