肺移植慢性排异反应动物模型研究进展  

Advances in research on animal models of chronic rejection after lung transplantation

作　　者：周文勇[1] 周晓慧[2] 范慧敏[1,2] 

机构地区：[1]同济大学附属东方医院胸心外科,上海200120 [2]同济大学东方转化医学研究中心,上海200120

出　　处：《中国实验动物学报》2015年第2期199-204,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(81273263;81202332);上海市科学技术委员会(11JC1410800;801);上海市医学重点专科建设(ZK2012A27);上海领军人才(2012053);浦东新区卫生系统领先人才培养(PWR12011-01);上海市浦东新区卫生系统重点学科群(Grant No.PWZxq2014-01)

摘　　要：慢性排异反应是导致肺移植后期移植失败的主要原因。闭塞性细支气管炎(obliterative bronchiolitis,OB)是肺移植后慢性排异反应的最主要病理学特征改变。而动物模型在肺移植慢性排异反应研究过程中,起到了不可或缺的作用。到目前为止,已经有多种动物模型被建立并用来模拟人类肺移植后中、远期慢性排异反应。但这些动物移植模型都或多或少存在缺陷。近年来,小鼠原位肺移植模型为研究OB提供了潜在可能。本文通过回顾各类肺相关移植模型的建立,对其优缺点进行分析比较,探讨今后肺移植慢性排异疾病模型建立的可能途径。The most important cause of late mortality after lung transplantation is obliterative bronchiolitis （ OB） . It is clear that a good animal model is indispensable to further unravel and clarify the pathogenesis of bronchiolitis obliterans syndrome （ BOS） .Many animal models have been developed to study BOS, however, so far, none of these models truly mimics the human condition.In recent years mouse models of orthotopic lung transplantation have been established, which provide potential possibilities for further studies of OB/BOS after lung transplantation.The aim of this article was to review the pros and cons of those animal models, and discuss the possible approaches to establish animal models of chronic rejec-tion after lung transplantation.

关 键 词：肺移植 慢性排异 闭塞性细支气管炎 动物模型 

分 类 号：Q95-33[生物学—动物学] R617[医药卫生—外科学]