TNF-α基因-308位点多态性与新疆维吾尔族、哈萨克族人群中支气管哮喘的关系  

Relationship between tumor necrosis factor-αgene-308 promoter polymorphism and susceptibility to development of bronchial asthma in Uighur and Kazakh population in Xinjiang

作　　者：朱佳[1] 李忠凯[1] 凌敏[1] 

机构地区：[1]新疆维吾尔自治区人民医院呼吸二科,新疆乌鲁木齐830000

出　　处：《西安交通大学学报（医学版）》2015年第3期383-386,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：中华医学会慢性呼吸道疾病专项基金资助(No.07010160024)~~

摘　　要：目的探讨TNF-α基因-308位点多态性与新疆维吾尔族、哈萨克族人群中支气管哮喘(BA)的相关性。方法以新疆维吾尔族、哈萨克族人群中BA发病组和对照组均60例为研究对象,通过PCR产物直接测序法检测TNF-α基因-308位点的多态性分布,并统计分析TNF-α不同基因型与新疆维吾尔族、哈萨克族人群中BA的相关性。结果维吾尔族、哈萨克族的BA发病组和对照组中均以GG基因型为主,在两民族人群中GG、GA、AA三种基因型频率有统计学差异(P<0.05),等位基因G和A之间亦有统计学差异(P<0.05);调整年龄、性别等影响因素后,两组之间仍有统计学差异(P<0.05)。结论 TNF-α基因-308位点的多态性与新疆维吾尔族、哈萨克族BA的易感性相关,携带AA或GA基因型患者发病风险较高。Objective To investigate the relationship between the polymorphism of the tumor necrosis factor-αgene-308 promoter and bronchial asthma （BA）in Uighur and Kazakh population in Xinjiang.Methods PCR product sequencing method was used to detect the polymorphism distribution of TNF-αgene in 60 BA patients and 60 controls among Xinjiang Uighur and Kazakh population.Then we analyzed the association between different TNF-αgenotypes and BA in Uighur and Kazakh population.Results The distribution of GG,GA and AA genotype was significantly different between the two groups.Statistical analysis showed that BA group had a significantly higher TNF-αA allele frequency than that of the control one （P 〈0.05）.After adjustment for sex and age,we found the A allele was a risk factor for BA pathogenesis （P 〈0.05）.Conclusion The polymorphism of TNF-α gene-308 may be associated with the susceptibility to BA in Xinjiang Uighur and Kazakh population,so TNF-α gene-308 may be considered as a genetic marker for early identification of individuals at high risk for BA,which may play an important role in preventing the development of BA in clinical practice.

关 键 词：支气管哮喘 多态性 TNF-Α基因 维吾尔族 哈萨克族 新疆 

分 类 号：R563.9[医药卫生—呼吸系统]