妇炎舒胶囊对慢性子宫内膜炎大鼠的治疗作用及其机制  

The therapeutic effects of Fuyanshu Capsule on chronic endometritis in rats

作　　者：黄谱[1] 周筠[2] 崔刚[3] 杨宝德[2] 赵文宝[3] 刘传镐[2] 胡浩[2] 

机构地区：[1]西安交通大学医学部第一附属医院妇产科,陕西西安710061 [2]西安交通大学医学部药理学系,陕西西安710061 [3]西安交通大学医学部病理学系,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2015年第3期404-407,413,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省科学技术研究发展计划项目资助(No.2013K21-22-01)~~

摘　　要：目的观察妇炎舒胶囊对苯酚胶浆剂致子宫内膜炎大鼠模型的影响,探讨其抗炎作用机制。方法雌性SD大鼠60只随机分为6组:假手术组(蒸馏水10mL/kg)、模型组、金鸡胶囊组(0.65g/kg)、妇炎舒胶囊大剂量组(1.8g/kg)、妇炎舒胶囊中剂量组(0.9g/kg)、妇炎舒胶囊小剂量组(0.45g/kg)。采用子宫内注射苯酚胶浆剂致子宫内膜炎大鼠模型,连续给药28d后,检测大鼠子宫内膜的组织病理学改变,以及血清肿瘤坏死因子(TNF-α)及白细胞介素-2(IL-2)的变化。结果妇炎舒胶囊可降低大鼠子宫卵巢脏体比值,抑制病变子宫肿胀,改善子宫内膜上皮细胞增生、变性、坏死及炎细胞浸润等病理改变;大剂量妇炎舒胶囊还可降低大鼠血清IL-2水平。结论妇炎舒胶囊对大鼠子宫内膜炎有治疗作用,其抗炎作用机制可能与降低IL-2水平有关。Objective To observe the effects of Fuyanshu Capsule on phenol mucilage-induced endometritis rats and the possible anti-inflammation mechanism of the therapeutic effects.Methods Chronic endometritis in rats was induced by injection of phenol mucilage suspension into the uterus.Sixty female SD rats were randomly divided into 6 groups,namely,sham-operation group （distilled water,10mL/kg）,model group,Jinji capsule group （0.65 g/kg）,and Fuyanshu Capsule groups （1.8 g/kg,0.9 g/kg and 0.45 g/kg）.After the rats were treated 28 days with corresponding medicine by intragastric administration,the pathology of the endometrium and changes of tumor necrosis factor α（TNF-α）and interleukin-2 （IL-2）levels were detected to evaluate the effects of Fuyanshu Capsule. Results Fuyanshu Capsule （1.8 g/kg and 0.9 g/kg）ameliorated the body weight reduction caused by endometritis in rats.Fuyanshu Capsule （1.8 g/kg,0.9 g/kg and 0.45 g/kg）reduced the ratio of the swelling uterus and ovaries to body weight of the rats.It ameliorated obviously the hyperplasia,necrosis and degeneration of endometrial epithelia and infiltration of inflammatory cells.The capsule （1.8 g/kg）decreased the serum IL-2 level in the rats with phenol mucilage-induced endometritis. Conclusion The anti-inflammatory effect of Fuyanshu Capsule on chronic endometritis induced by phenol mucilage in rats may be related to the decrease of IL-2 level.

关 键 词：妇炎舒胶囊 子宫内膜炎 苯酚胶浆 炎症因子 

分 类 号：R285.5[医药卫生—中药学]