炎性反应及免疫反应与病理性瘢痕研究进展  

RESEARCH PRO GRESS OF IMMUNO-INFL AMMATORY RESPONSE AND PATHOLOGICAL SCAR

作　　者：陈燕[1] 谢利红[1] 章杰[1] 付建华[1] 

机构地区：[1]南昌大学第一附属医院整形外科,南昌330006

出　　处：《中国修复重建外科杂志》2015年第5期640-644,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(81460295);江西省卫生计生委科技计划资助项目(20155201)~~

摘　　要：目的对病理性瘢痕形成过程中涉及的炎性反应及免疫反应的相关研究作一综述。方法广泛查阅近年来病理性瘢痕形成机制相关文献,对在其形成过程中所参与的炎性反应与免疫反应进行综述。结果病理性瘢痕的形成与炎性反应及免疫反应有关,一些炎性因子会促进免疫细胞活化,诱导免疫细胞释放细胞因子,加重炎性反应,而炎性反应也会影响免疫反应程度,两者可通过炎性免疫细胞及介质共同作用促进病理性瘢痕的形成。结论病理性瘢痕的形成不仅与炎性反应有关,还涉及免疫反应,而免疫反应是近年来病理性瘢痕机制研究中的新进展,进一步深入研究炎性免疫反应将为病理性瘢痕的防治策略提供新的思路与相应依据。Objective To review the research progress of the roles of inflammation and immune response in the formation of pathological scar.Methods The recent literature concerning the formation mechanism of pathological scar was extensively consulted,inflammation and immune response involved in the formation of pathological scar was reviewed.Results The formation of pathological scar is associated with inflammation and immune response,some inflammatory factors will promote the activation of immune cells,then induce immune cells releasing cytokines and aggravate inflammatory response.However,inflammation response also affects the level of immune response.So they work together to promote the formation of pathological scar by the immuno-inflammatory cells and media.Conclusion The formation of pathological scar is not only related to inflammation response,but also involves in immune response.Moreover,immune response is the new progress in the study of pathological scar mechanism in recent years.Further research of immuno-inflammatory response will provide new ideas and corresponding basis for the prevention of pathological scar.

关 键 词：病理性瘢痕 形成机制 炎性反应 免疫反应 

分 类 号：R622[医药卫生—整形外科]