3.0T磁共振R2＊值评价足月出生婴儿脑深部灰质核团年龄相关性铁沉积  

Age-related iron deposition of the full-term infants deep gray nuclei detected by R2＊ values on 3. 0T MR

作　　者：宁宁[1,2] 张育苗[1] 张雷[1] 李彦彦[1] 李欢[1] 杨健[1] 

机构地区：[1]西安交通大学医学院第一附属医院影像科,陕西西安710061 [2]西安交通大学医学院第二附属医院核医学科,陕西西安710004

出　　处：《中国医学影像技术》2015年第5期706-710,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金面上项目(81471631;81171317);教育部新世纪优秀人才计划(NCET-11-0438);国家卫计委临床重点专科基金

摘　　要：目的 采用3.0T MR R2＊值观察婴儿脑深部灰质核团铁沉积与周龄的关系。方法 纳入婴儿53名,校正周龄（PMA）37~92周。采用GE 3.0T磁共振扫描仪进行增强T2＊加权血管成像（ESWAN）序列扫描,测量脑内双侧深部灰质核团（尾状核、壳核、苍白球、丘脑、红核和黑质）的R2＊值。对各部位R2＊值与脑铁含量进行相关分析,并分析R2＊值与PMA的关系。结果 婴儿期脑深部灰质核团R2＊值与脑铁含量均呈正相关（P均〈0.001）。尾状核、壳核、苍白球、丘脑、红核和黑质的R2＊值与PMA均呈正相关（r=0.865、0.818、0.893、0.844、0.742和0.834,P均〈0.001）。结论 婴儿期脑深部灰质核团的R2＊值随周龄增大逐渐增加,其可反映局部脑铁沉积随周龄的增加。Objective To investigate age-related iron deposition of the infants＂ deep gray nuclei detected by R2 values on 3.0T MR. Methods Fifty-three infants whose postmenstrual age （PMA） ranged from 37 to 92 weeks were examined by enhanced T2 star weighted angiography （ESWAN） in 3.0T MR system. The R2 values were measured from the deep gray nuclei （caudate nucleus, putamen, globus pallidus, thalamus, red nucleus and substantia nigra）. Correlation analysis were performed to explore the relation between the R2 values and iron concentrations, PMA. Results R2 values had a positive correlation with the iron concentrations in the deep gray nuclei （all P〈0. 001）. The significantly positive correla- tions between the R2 values of caudate nucleus, putamen, globus pallidus, thalamus, rednucleus and nigra and PMA were found （r=0. 865, 0. 818, 0. 893, 0. 844, 0. 742 and 0. 834, respectively, all P〈0. 001）. Conclusion R2 values increase by age in the deep gray nuclei, which may reflect the age-related iron deposition in infants.

关 键 词：婴儿 年龄 灰质 铁 磁共振成像 横向弛豫率 

分 类 号：R72[医药卫生—儿科] R445.2[医药卫生—临床医学]