乳腺癌与MICA基因多态性的相关性研究  

A Research on the Correlation between Breast Cancer and MICA Alleles Polymorphism

作　　者：郭家权[1] 陈纯静[1] 陈恩[1] 陈富超[1] 罗奇志[1] 余平[1] 

机构地区：[1]中南大学基础医学院免疫学系,湖南长沙410008

出　　处：《激光生物学报》2015年第2期170-174,169,共6页Acta Laser Biology Sinica

基　　金：国家自然科学基金项目(81371864)

摘　　要：目的:研究海南汉族人群MICA等位基因的多态性与乳腺癌的相关性。方法:采用PCR-SSP和PCRSBT方法对样本MICA等位基因的多态性进行检测分析。结果:乳腺癌患者中有检测出10种MICA等位基因,其中MICA*002/019基因型频率较对照组显著偏低(OR=0.32,Pc<0.05)。结论:MICA*002/019基因型可能与乳腺癌的保护相关。Objective：To study the correlation MICA gene polymorphism and haplotype diversity with breast cancer in han nationality of Hainan.Methods：PCR-SSP and PCR-SBT were used to detect and analyze the gene polymorphism of MICA.Results：10 allelic genes were found in patients of breast cancer,and the frequency of MICA＊002/019 was sig-nificantly lower than that of the control group （OR=0.32,Pc〈0.05）.Conclusions：MICA＊002/019 allelic gene pol-ymorphism may be associated with breast cancer protection.

关 键 词：MICA 基因 基因多态性 乳腺癌 

分 类 号：R392[医药卫生—免疫学]