自然周期与促排卵周期宫腔内人工授精临床效果分析  

Analysis on clinical effects of natural cycles and controlled ovarian stimulation cycles of intrauterine insemination

作　　者：牛吉峰[1] 刘格琳[1] 韩冰兵[1] 

机构地区：[1]郑州大学附属洛阳中心医院生殖中心,河南洛阳471000

出　　处：《中国妇幼保健》2015年第15期2388-2389,2424,共3页Maternal and Child Health Care of China

摘　　要：目的:比较自然周期与不同方案促排卵周期宫腔内人工授精(IUI)的临床结局。方法:将480个IUI周期分为自然周期组(n=132)、克罗米芬组(CC组,n=144)和克罗米芬+尿促性腺激素组(CC+HMG组,n=204),比较两组患者的妊娠率和流产率。结果:自然周期组、CC组和CC+HMG组患者妊娠率分别为7.6%(10/132)、17.9%(24/134)和18.6%(38/204),差异有统计学意义(χ2=7.672,P<0.05);而CC组与CC+HMG组患者妊娠率差异无统计学意义(P>0.05)。3组间流产率分别为10.0%(1/10)、16.7%(4/24)和18.4%(7/38),差异无统计学意义(χ2=0.346,P>0.05);CC组与CC+HMG组患者流产率差异无统计学意义(P>0.05)。结论:应用尿促性腺激素联合克罗米芬促排卵治疗可以增加宫腔内人工授精的妊娠率,值得在临床推广应用。Objective： To compare the clinical outcomes of natural cycles and different schemes of controlled ovarian stimulation cycles of intrauterine insemination （IUI） . Methods： A total of 480 IUI cycles were divided into natural cycle group （n = 132 ）, clomi- phene group （CC group, n = 144）, and clomiphene combined with human menopausal gonadotrophin （CC＋HMG group, n= 204） , the preg- nancy rates and abortion rates in the three groups were compared. Results： The pregnancy rates in natural cycle group, CC group and CC＋ HMG group were 7. 6% （10/132）, 17. 9% （24/134）, and 18.6% （38/204）, respectively, there were statistically significant differences （χ^2 =7. 672, P〈0. 05 ）; there was no statistically significant difference between CC group and CC＋HMG group （P〉0. 05 ） . The abortion rates in the three groups were 0. 0% （0/10）, 16. 7% （4/24）, and 18.4% （7/38）, respectively, there was no statistically significant difference （X2 =0. 346, P〉0. 05）; there was no statistically significant difference between CC group and CC＋HMG group （P〉0. 05 ） . Conclusion ： CC combined with HMG used for ovulation induction can increase pregnancy rate of IUI, which is worthy of clinical populariza- tion and application.

关 键 词：宫腔内人工授精 促排卵 自然周期 妊娠率 

分 类 号：R711.6[医药卫生—妇产科学]