奥沙利铂所致急性神经兴奋症状的观察  

OXALIPLATIN-INDUCED SYMPTOMS OF ACUTE NERVE EXCITABILITY:A CLINICAL OBSERVATION

作　　者：王小艳 王志伟 杨萍萍 李海鹰 

机构地区：[1]青岛市中心医院干部保健科,山东青岛266042 [2]青岛市中心医院肛肠外科,山东青岛266042

出　　处：《齐鲁医学杂志》2015年第2期149-151,共3页Medical Journal of Qilu

摘　　要：目的探讨应用奥沙利铂化疗病人急性神经兴奋症状的发生情况。方法结直肠癌病人80例,接受以奥沙利铂为基础的化学治疗(FOLFOX-4、FOLFOX-6或XELOX方案),分别于应用奥沙利铂化疗的第1个周期、所有化疗方案结束后进行临床神经功能评价。在评价时,病人被要求回答是否存在及存在哪些急性神经兴奋症状。结果有66例病人出现典型的急性周围神经炎的症状,其中36例(54%)同时出现非典型的神经兴奋症状,包括气短(32%)、下颌痉挛(26%)、抽筋(20%)、吞咽困难(18%)、声音改变(4%)、视力改变(1%)、眼睑下垂(1%)。奥沙利铂化疗所引起的非典型神经兴奋症状与病人的化疗方案、奥沙利铂的累积量和病人的年龄间没有显著关系(P>0.05)。结论奥沙利铂化疗引起的急性非典型的神经兴奋症状有很高的发病率,并可能逐渐进展为慢性,应对这些病人进行密切监测。Objective To investigate the symptoms of acute nerve excitability （ANE） in patients induced by oxaliplatin chemotherapy. Methods Eighty patients with colorectal cancer treated with oxaliplatin-based therapy （FOLFOX-4, FOLFOX- 6, or XELOX program） were evaluated in regard to their nerve function on the first week of chemotherapy. The patients were asked to answer if they had or which ANE involved. Results Typical symptoms of acute peripheral neuritis presented in 66 patients. Of whom, 36 （54%） appeared atypical symptoms of nervous excitement including shortness of breath （32%）, jaw spasm （26%）, faseiculations （20%）, difficulty in swallowing （18%）, voice change （4%）, visual change （1%） and ptosis （1%）. ANE caused by oxaliplatin chemotherapy was not statistically correlated with therapeutic regimen, cumulative dose of oxaliplatin or patient age. Conclusion There is a high incidence of acute nerve excitability caused by oxaliplatin chemotherapy, which can gradually progress to chronic. A close monitoring is needed.

关 键 词：奥沙利铂 药物毒性 症状和体征 

分 类 号：R453.9[医药卫生—治疗学]