烟酸对兔骨性关节炎骨桥蛋白表达的影响  

Effect of nicotinic acid on expression of osteopontin in rabbit of knee osteoarthritis

作　　者：王志勇[1] 王永安[1] 熊敏[1] 余化龙[1] 李军[1] 何宁[1] 刘志刚[1] 曾云[1] 

机构地区：[1]湖北医药学院附属东风医院骨科研究所,十堰442008

出　　处：《中华实验外科杂志》2015年第5期1122-1123,共2页Chinese Journal of Experimental Surgery

摘　　要：目的 检测兔骨性关节炎的膝关节滑液中以及软骨下骨中骨桥蛋白（OPN）的表达,探讨烟酸对骨桥蛋白表达的影响.方法 取新西兰大白兔采用改良Hulth法建立兔膝骨性关节炎模型,治疗组（12只）采用200 mg/（kg·d）烟酸的提取药物灌胃,对照组（12只）采取普通饮食喂养作为对照组.实验前后取关节骨组织,采用免疫组织化学法检测关节骨组织中OPN的含量.结果 与对照组[（2 390.29±291.31） ng/L]比较,烟酸组OPN含量[（2 140.19±211.19） ng/L]显著降低.两组差异有统计学意义（P＜0.05）.结论 烟酸能够有效降低OPN含量,具有促进骨关节炎的修复的作用.Objective To investigate effect of nicotinic acid on expression of osteopontin in rabbit of knee osteoarthritis by detect the expression of osteopontin （OPN） in the rabbit＇ s synovial fluid and endochondral bone.Methods New Zealand Rabbits were made into knee osteoarthritis by improvement Hulth,12 of treatment group were supplemented with niacin by using stomach tube [200 mg/（kg·d）],12of the control group were supplemented with ordinary diet.Endochondral bone were taken out before and after the experiment,and detect the content of OPN by immunocytochemistry.Results Compared with the control group [（2 390.29 ± 291.31） ng/L],the expression of OPN of niacin group [（2 140.19 ± 211.19） ng/L] decrease obviously,there were statistical differences between the control group and the niacin group （P 〈 0.05）.Conclusion Nicotinic acid can helps repair osteoarthritis by effectively lowered the content of OPN.

关 键 词：烟酸 骨关节炎 骨桥蛋白 

分 类 号：R965[医药卫生—药理学]