对乙酰氨基酚超剂量使用致肝毒性及防治概述  

Overdose Acetaminophen Induced Liver Toxicity and Treatment Overview

作　　者：于洋[1] 范捷[1] 

机构地区：[1]江汉大学附属医院,武汉430015

出　　处：《药物流行病学杂志》2015年第5期305-308,共4页Chinese Journal of Pharmacoepidemiology

摘　　要：目前广泛应用的处方药或非处方药中很多含有对乙酰氨基酚,近年其超剂量使用所致肝毒性日益引起临床医师及管理部门的重视。本文对对乙酰氨基酚的肝毒性相关的文献进行回顾分析,总结对乙酰氨基酚超剂量使用所致肝毒性的药物流行病学、致病机制、与剂量的相关性及中毒后的相关治疗措施,旨在为临床医师安全合理使用该药提供有价值的参考。The current widely used prescription and non prescription drugs in many contain acetaminophen,in recent years overdose acetaminophen induced liver toxicity caused by the increasingly attention of the clinician and management. The article through to the hepatotoxicity of acetaminophen related literature is reviewed,summary of pharmacoepidemiology,pathogenesis of acetaminophen induced liver toxicity,the correlation between liver toxicity and drug dose,and the relevant treatment,for the purpose of safe and reasonable to provide clinicians with the drug valuable reference.

关 键 词：对乙酰氨基酚 N-乙酰半胱氨酸 肝毒性 

分 类 号：R971.1[医药卫生—药品]