血清胸苷激酶1在慢性阻塞性肺疾病急性加重期患者中的临床价值  

Expression and clinical value of serum thymidine kinase 1 in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：刘茵[1] 金蒙蒙[1] 钱震东 陈梅莉[1] 黄锐[1] 杜婷[1] 张妍蓓[1] 

机构地区：[1]安徽医科大学第一附属医院老年呼吸内科,合肥市230022 [2]安徽省铜陵市立医院呼吸内科,244000

出　　处：《实用医学杂志》2015年第9期1431-1433,共3页The Journal of Practical Medicine

基　　金：安徽省高校省级自然科学研究重点项目(编号:KJ2011A178);安徽省自然科学基金项目(编号:1208085MH146)

摘　　要：目的:探讨血清胸苷激酶1(s TK1)在慢性阻塞性肺疾病急性加重期(AECOPD)患者中的表达及在AECOPD治疗中的临床意义。方法:回顾性分析104例AECOPD治疗后患者的临床资料,根据治疗后情况分为治疗有效组70例及治疗无效组34例,应用免疫印迹-增强化学发光法检测治疗前后s TK1水平的差异,并将治疗后两组的s TK1与CRP的表达进行相关性分析。结果:有效组患者治疗后的s TK1与CRP的水平较治疗前明显降低,差异有统计学意义(均P<0.05),无效组两者的水平较治疗前降低,但差异无统计学意义(P>0.05);104例患者治疗前后s TK1与CRP的表达有相关性(均P<0.05)。结论:s TK1对AECOPD患者病情的评估及疗效的判断具有参考价值。Objective To investigate the relations and evaluation value of serum thymidine kinase 1 （sTK1） in the treatment of patients withacute exacerbation of chronic obstructive pulmonarydisease （AECOPD）. Methods The retrospective treating studies were performed on 104 patients with AECOPD , sTK1 level was de-tected by chemiluminescence dot-blot assay before and after treatment , and the correlation between the expression of sTK1 and CRP after treatment in the two groups was analyzed. Results The levels of sTK1 and CRP in the ef-fective group significantly lowered after treatment （P 〈0.05）. The expression of sTK1 in the effective group and in the ineffective group after treatment was significantlycorrelated with CRP （P 〈0.05）. Conclusion sTK1 can be used as a valuable indicator to evaluate the severity of AECOPD and to estimate the efficacy of AECOPD thera-py.

关 键 词：慢性阻塞性肺疾病急性加重期 血清胸苷激酶1 疗效 

分 类 号：R563.9[医药卫生—呼吸系统]