治疗慢性阻塞性肺疾病气道黏液高分泌临床意义  

Clinical significance of airway mucus hypersecretion in chronic obstructive pulmonary disease

作　　者：田攀文[1] 文富强[1] 

机构地区：[1]四川大学华西医院呼吸内科,成都610041

出　　处：《中国实用内科杂志》2015年第5期382-385,共4页Chinese Journal of Practical Internal Medicine

基　　金：国家十二五科技支撑课题(2012BAI05B02);四川省科技厅科技支撑计划项目(2013SZ0001)

摘　　要：气道黏液高分泌是慢性阻塞性肺疾病(简称慢阻肺)的重要病理生理特征之一。慢阻肺患者的气道黏液高分泌可加速患者肺功能下降、导致患者生活质量变差、急性加重频率增加、住院率和病死率升高。针对慢阻肺患者气道黏液高分泌的治疗包括非药物治疗和药物治疗。非药物治疗措施为戒烟和物理康复治疗。药物治疗包括祛痰剂和黏液溶解剂、甲基黄嘌呤和β受体激动剂、抗胆碱药、糖皮质激素、磷酸二酯酶4抑制剂、抗氧化剂和大环内酯类抗生素等。一些新药正处在临床研究阶段,已显示出治疗前景。Mucus hypersecretion is one of the most important features of the chronic obstructive pulmonary disease（COPD）. Mucus hypersecretion in COPD patients results in several important outcomes such as rapid decline of lung function, poor quality of life, and high rate ofexacerbations, hospitalizations and mortality. Non-pharmacologic treatments for mucus hypersecretion in COPD include smoking cessation and physical rehabilitation. Pharmacologic therapies include expectorants, mucolytics, methylxanthines, beta-adrenergic receptor agonists, anticholinergics, glucocorticoids, phosphodiesterase-4 inhibitors, antioxidants, and antibiotics. Novel drugs are currently used in clinical trials, showing promising propects.

关 键 词：肺疾病 慢性阻塞性 黏液高分泌 

分 类 号：R562[医药卫生—呼吸系统]