胺碘酮联合阿托伐他汀预防冠状动脉搭桥围术期房颤的临床观察  

Clinical Observation of Amiodarone Combined with Atorvastatin on Perioperative Prevention of Atrial Fibrillation in Coronary Artery Bypass Grafting

作　　者：胡国智[1] 罗萍[1] 

机构地区：[1]武汉亚洲心脏病医院心外科,武汉430022

出　　处：《中国药房》2015年第15期2057-2059,共3页China Pharmacy

摘　　要：目的:观察胺碘酮联合阿托伐他汀预防冠状动脉搭桥围术期房颤的临床疗效和安全性。方法:将120例冠状动脉狭窄患者随机均分为对照组和研究组。两组患者行冠状动脉搭桥术后均给予氯吡格雷、阿司匹林、酒石酸美托洛尔等常规治疗。在此基础上,对照组患者给予盐酸胺碘酮片0.2 g,口服,每日3次,1周后根据患者的病情改善情况调整剂量。研究组患者在对照组治疗的基础上给予阿托伐他汀钙片20 mg,口服,每晚1次。两组患者均术前用药1周,疗程均为1个月。观察两组患者的临床疗效,房颤发生率,治疗前后左心房内径、P波离散度及不良反应发生情况。结果:研究组患者总有效率显著高于对照组,房颤发生率显著低于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组患者左心房内径恢复至同组治疗前,差异无统计学意义(P>0.05),对照组患者左心房内径显著高于同组治疗前;两组患者P波离散度均显著高于同组治疗前,但研究组低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论:胺碘酮联合阿托伐他汀可有效控制左心房内径、维持窦性心律、控制房颤,且安全性较好。OBJECTIVE：To observe the clinical efficacy and safety of amiodarone combined with atorvastatin on perioperative prevention of atrial fibrillation in coronary artery bypass grafting（CABG）.METHODS：120 patients with coronary artery stenosis were randomly divided into control group and research group.All patients were given routine treatment after CABG,including plavix,aspirin and metoprolol tartaric acid,etc.Based on it,the patients in control group were orally given amiodarone 0.2 g,3 times a day;after 1 week,the dose was adjusted according to the patient＇s condition.Patients in research group were orally given atorvastatin 20 mg based on the treatment in control group,qn.The patients were administrated for 1 week before operation and the course was 1 month.The clinic data was observed,including clinical efficacy,the incidence of atrial fibrillation,left atrial diameter,P wave dispersion before and after treatment and ADR.RESULTS：The total effective rate in research group was significantly higher than control group,and the incidence of atrial fibrillation was significantly lower than control group,with significant differences（P〈0.05）.After treatment,the left atrial diameter in research group was recovered,with no significant difference（P〉0.05）;the left atrial diameter in control group was higher than before and research group.P wave dispersion was significantly higher than before,research group was significantly lower than control group,with significant differences（P〈0.05）.There were no obvious adverse reactions during treatment.CONCLUSIONS：Amiodarone combined with atorvastatin can effectively control the left atrial diameter and atrial fibrillation and maintain sinus rhythm with good safety.

关 键 词：冠状动脉搭桥术 房颤 预防 胺碘酮 阿托伐他汀 

分 类 号：R654.2[医药卫生—外科学]