施保利通片联合利巴韦林治疗小儿疱疹性咽峡炎的临床观察  

Clinical Observation of Esberitox Tablet Combined with Ribavirin in the Treatment of Infantile Herpangina

作　　者：王鹤[1] 张金环[1] 张君[1] 刘圣平[2] 

机构地区：[1]潍坊市妇幼保健院临床药学科,山东潍坊261011 [2]潍坊市妇幼保健院综合儿科,山东潍坊261011

出　　处：《中国药房》2015年第15期2068-2069,共2页China Pharmacy

摘　　要：目的:观察施保利通片联合利巴韦林治疗小儿疱疹性咽峡炎的临床疗效和安全性。方法:将117例疱疹性咽峡炎患儿随机分为观察组(59例)和对照组(58例)。两组患儿体温高时均予以物理降温及口服退热药,合并感染者使用抗菌药物等常规治疗。在此基础上,对照组患儿给予利巴韦林气雾剂0.5 mg,喷于口腔、咽峡,第1小时喷2次,后每2小时喷1次,2 d后每日喷4~6次,每次均2喷。观察组患儿在对照组治疗的基础上给予施保利通片,<1岁患儿1片,≤6岁患儿l^2片,7~12岁患儿2片,口服,每日3次。两组患儿疗程均为5 d。观察两组患儿的临床疗效、各临床症状消失时间及不良反应发生情况。结果:观察组患儿总有效率显著高于对照组,退热时间、疱疹溃疡消失时间均显著短于对照组,差异均有统计学意义(P<0.05)。两组患儿不良反应发生率比较差异无统计学意义(P>0.05)。结论:施保利通片联合利巴韦林治疗疱疹性咽峡炎较单用利巴韦林疗效更显著,安全性较好。OBJECTIVE：To observe the clinical efficacy and safety of Esberitox tablet combined with ribavirin in the treatment of infantile herpangina.METHODS：Totally 117 children with herpangina were randomly divided into observation group（59 cases）and control group（58 cases）.All the children were given routine treatment,including physical cooling,oral antipyretic to patients with high body temperature and antibacterial drugs to patients with infection,etc.Based on it,the children in control group were given Ribavirin aerosol 0.5 mg to oral cavity and isthmus of fauces,2 times in the first hour,then once every 2 hours,4-6 times a day after 2 days,2 doses each time.Children in observation group were orally given Esberitox tablets based on the treatment of control group,one tablet each time to infants,1-2 tablet（s）each time to children under 6 years old,and 2 tablets each time to children from 7 to 12 years old,3 times a day.The course of both was 5 d.The clinic data was observed,including clinical efficacy,disappearance time of clinical symptoms and the incidence of adverse reactions.RESULTS：The total effective rate in observation group was significantly higher than control group and the disappearance time of defervesce and herpes ulcers were significantly shorter than control group,with significant differences（P〈0.05）.There were no significant differences in the incidence of adverse reactions between 2 groups（P〉0.05）.CONCLUSIONS：Esberitox tablet combined with ribavirin is significantly better than only ribavirin in the treatment of herpangina with good safety.

关 键 词：施保利通片 利巴韦林 疱疹性咽峡炎 疗效 安全性 

分 类 号：R725[医药卫生—儿科]