丁二磺酸腺苷蛋氨酸联合扶正化瘀胶囊治疗乙型肝炎病毒肝硬化的临床观察  

Clinical Observation of Ademetionine-1,4-Butanedisulfonate Combined with Fuzheng Huayu Capsules in the Treatment of HBV-cirrhosis

作　　者：陈艳 辛隽 

机构地区：[1]成都市公共卫生临床医疗中心,成都610000

出　　处：《中国药房》2015年第15期2082-2084,共3页China Pharmacy

摘　　要：目的:观察丁二磺酸腺苷蛋氨酸联合扶正化瘀胶囊治疗乙型肝炎病毒(HBV)肝硬化的临床疗效和安全性。方法:将110例HBV肝硬化患者随机均分为对照组和观察组。两组患者均接受保肝等常规治疗。在此基础上,对照组患者给予丁二磺酸腺苷蛋氨酸片500 mg,口服,bid;观察组患者在对照组治疗的基础上给予扶正化淤胶囊5粒,口服,tid。两组患者疗程均为24周。观察两组患者治疗前后肝功能指标[总胆红素(TBIL)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、白蛋白(ALB)]、门静脉血流动力学指标,乙型肝炎病毒脱氧核糖核酸(HBV-DNA)阴转率及不良反应发生情况。结果:观察组患者总有效率、HBV-DNA阴转率均显著高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者TBIL、AST、ALT、门静脉宽度均显著低于同组治疗前,且观察组低于对照组;ALB、门静脉流速均显著高于同组治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论:丁二磺酸腺苷蛋氨酸联合扶正化瘀胶囊治疗HBV肝硬化较单用丁二磺酸腺苷蛋氨酸疗效更显著,安全性相似。OBJECTIVE：To observe the clinical efficacy and safety of ademetionine-1,4-butanedisulfonate combined with Fuzheng huayu capsules in the treatment of HBV-cirrhosis.METHODS：110 patients with HBV-cirrhosis were randomly divided into control group and observation group.All patients were given routine treatment,including liver protection and so on.Based on it,patients in control group were orally given ademetionine-1,4-butanedisulfonate 500 mg,twice a day;patients in observation group were orally given Fuzheng huayu capsules 5 particles,3 times a day,based on the treatment of control group.The course of both was 24 weeks.The clinic data was observed,including the changes of liver functions（TBIL,AST,ALT and ALB）,portal hemodynamics index and the negative conversion rate of HBV-DNA before and after treatment and ADR.RESULTS：The total effective rate and the negative conversion rate of HBV-DNA in observation group were significantly higher than control group,with significant difference（P〈0.05）.After treatment,the TBIL,AST,ALT and portal venous width in 2 groups were significantly lower than before and observation group was lower than control group;ALB and portal venous velocity were significantly higher than before and observation group was higher than control group,with significant differences（P〈0.05）.There were no obvious adverse reactions during the treatment.CONCLUSIONS：Ademetionine-1,4-butanedisulfonate combined with Fuzheng huayu capsules has more obvious efficacy than only ademetionine-1,4-butanedisulfonate in the treatment of HBV-cirrhosis with similar safety.

关 键 词：丁二磺酸腺苷蛋氨酸 扶正化淤胶囊 乙型肝炎病毒肝硬化 疗效 安全性 

分 类 号：R512.6[医药卫生—内科学]